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Rhophylac Dosage

Generic name: human rho(d) immune globulin
Dosage form: injection

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This dosage information does not include all the information needed to use Rhophylac safely and effectively. See full prescribing information for Rhophylac.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

As with all blood products, patients should be observed for at least 20 minutes following administration of Rhophylac.

Preparation and Handling

  • ​Rhophylac is a clear or slightly opalescent, colorless to pale yellow solution. Inspect Rhophylac visually for particulate matter and discoloration prior to administration. Do not use if the solution is cloudy or contains particulates.

  • ​Prior to intravenous use, ensure that the needle-free intravenous administration system is compatible with the tip of the Rhophylac glass syringe.

  • ​Do not freeze.

  • ​Bring Rhophylac to room temperature before use.

  • ​Rhophylac is for single use only. Dispose of any unused product or waste material in accordance with local requirements.

Suppression of Rh Isoimmunization

Rhophylac should be administered by intravenous or intramuscular injection. If large doses (greater than 5 mL) are required and intramuscular injection is chosen, it is advisable to administer Rhophylac in divided doses at different sites.

Table 1 provides dosing guidelines based on the condition being treated.

Table 1: Dosing Guidelines for Suppression of Rh Isoimmunization
Indication Timing of Administration Dose*
(Administer by Intravenous or Intramuscular Injection)
IU, international units; mcg, micrograms.
*
A 1500 IU (300 mcg) dose of Rhophylac will suppress the immunizing potential of ≥15 mL of Rh0(D)-positive RBCs.2
†
The dose of Rhophylac must be increased if the patient is exposed to >15 mL of Rh0(D)-positive RBCs; in this case, follow the dosing guidelines for excessive fetomaternal hemorrhage.
Rh-incompatible pregnancy
 
Routine antepartum prophylaxis
 At Week 28-30 of gestation 1500 IU (300 mcg)
 
Postpartum prophylaxis
(required only if the newborn is Rh0(D)-positive)
 Within 72 hours of birth 1500 IU (300 mcg)†
 
Obstetric complications
(e.g., miscarriage, abortion, threatened abortion, ectopic pregnancy or hydatidiform mole, transplacental hemorrhage resulting from antepartum hemorrhage)
 Within 72 hours of complication 1500 IU (300 mcg)†
 
Invasive procedures during pregnancy (e.g., amniocentesis, chorionic biopsy) or obstetric manipulative procedures (e.g., external version, abdominal trauma)
 Within 72 hours of procedure 1500 IU (300 mcg)†
 
Excessive fetomaternal hemorrhage
(>15 mL)
 Within 72 hours of complication 1500 IU (300 mcg) plus:
  • 100 IU (20 mcg) per mL fetal RBCs in excess of 15 mL if excess transplacental bleeding is quantified
    or
  • An additional 1500 IU (300 mcg) dose if excess transplacental bleeding cannot be quantified
Incompatible transfusions Within 72 hours of exposure 100 IU (20 mcg)
per 2 mL transfused blood or per 1 mL erythrocyte concentrate

ITP

For treatment of ITP, ADMINISTER RHOPHYLAC BY THE INTRAVENOUS ROUTE ONLY (see Preparation and Handling [2.1]). Do not administer intramuscularly.

A 250 IU (50 mcg) per kg body weight dose of Rhophylac is recommended for patients with ITP. The following formula can be used to calculate the recommended amount of Rhophylac to administer:

Dose (IU) × body weight (kg) = Total IU / 1500 IU per syringe = Number of syringes

Rhophylac should be administered at a rate of 2 mL per 15 to 60 seconds.

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