Relexxii Dosage

Generic name: METHYLPHENIDATE HYDROCHLORIDE 45mg
Dosage form: tablet, extended release
Drug class: CNS stimulants

Medically reviewed by Drugs.com. Last updated on Oct 30, 2023.

2.1 Pretreatment Screening

Prior to treating patients with RELEXXII, assess:

for the presence of cardiac disease (i.e., perform a careful history, family history of sudden death or ventricular arrhythmia, and physical exam) [see Warnings and Precautions ( 5.2)] .
the family history and clinically evaluate patients for motor or verbal tics or Tourette’s syndrome before initiating RELEXXII [see Warnings and Precautions ( 5.11)].

2.2 General Administration Information

Administer RELEXXII orally once daily in the morning with or without food.

Swallow RELEXXII whole with liquid. Do not chew, divide, or crush [see Warnings and Precautions ( 5.8)] .

2.3 Dosage Recommendations for Patients New to Methylphenidate

Table 1 includes the starting dosage and dosage recommendations for RELEXXII in pediatric patients 6 to 17 years and adults who are not currently taking methylphenidate or other stimulants.

Table 1: Dosage Recommendations for RELEXXII in Pediatric Patients 6 to 17 years and Adults

Patient Population	RELEXXII Recommended Starting Dosage	RELEXXII Dosage Range
Pediatric patients 6 to 12 years	18 mg once daily	18 mg to 54 mg once daily
13 to 17 years	18 mg once daily	18 mg to 72 mg once daily (not to exceed 2 mg/kg/day)
Adults 18 (up to 65 years)	18 mg or 36 mg once daily	18 mg to 72 mg once daily

2.4 Dosage Recommendations for Patients Currently Using Methylphenidate

The recommended starting dosage of RELEXXII for patients who are currently taking methylphenidate twice daily or three times daily at doses of 10 mg to 60 mg daily is provided in Table 2.

Table 2. Recommended Starting Dosage when Converting from Methylphenidate Regimens to RELEXXII

Current Methylphenidate Daily Dosage	Recommended Starting Dosage of RELEXXII
5 mg methylphenidate twice daily or three times daily	18 mg once daily in the morning
10 mg methylphenidate twice daily or three times daily	36 mg once daily in the morning
15 mg methylphenidate twice daily or three times daily	54 mg once daily in the morning
20 mg methylphenidate twice daily or three times daily	72 mg once daily in the morning

2.5 Dose Titration

Doses may be increased in 18 mg increments at weekly intervals for patients who have not achieved clinical response at a lower dose. Daily dosages above 54 mg in pediatric patients 6 to 12 years and above 72 mg in pediatric patients 13 to 17 years have not been studied and are not recommended. Daily dosages above 72 mg are not recommended in adults.

Dosage strengths of 27 mg, 45 mg, and 63 mg are available for additional titration options based on clinical response.