Norfloxacin Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for Urinary Tract Infection

Uncomplicated:
Due to Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis: 400 mg orally every 12 hours for 3 days
Due to other organisms: 400 mg orally every 12 hours for 7 to 10 days

Complicated: 400 mg orally every 12 hours for 10 to 21 days

Usual Adult Dose for Cystitis

Due to E coli, K pneumoniae, or P mirabilis: 400 mg orally every 12 hours for 3 days
Due to other organisms: 400 mg orally every 12 hours for 7 to 10 days

Usual Adult Dose for Prostatitis

Acute or chronic: 400 mg orally every 12 hours for 28 days

Usual Adult Dose for Gonococcal Infection - Uncomplicated

800 mg orally one time

Due to high rates of resistance, the Centers for Disease Control and Prevention do not recommend fluoroquinolones for treatment of gonococcal infections in the United States. Ceftriaxone or oral cefixime is recommended as first-line treatment of gonorrhea in the United States. Antimicrobial susceptibility patterns should be monitored.

Doxycycline therapy for 7 days (if not pregnant) or single-dose azithromycin is also recommended for possible coexisting chlamydial infection.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Campylobacter Gastroenteritis

(Not approved by FDA)

400 mg orally every 12 hours for 3 days
Immunocompromised patients may require therapy for 7 to 14 days.

Usual Adult Dose for Epididymitis - Non-Specific

(Not approved by FDA)

Nonsexually transmitted: 400 mg orally every 12 hours for 14 days

Usual Adult Dose for Pyelonephritis

(Not approved by FDA)

Mild infections: 400 mg orally every 12 hours for 14 days

Usual Adult Dose for Salmonella Enteric Fever

(Not approved by FDA)

400 mg orally every 12 hours for 7 to 14 days

Usual Adult Dose for Salmonella Gastroenteritis

(Not approved by FDA)

400 mg orally every 12 hours for 5 days; however, most cases are self-limiting and prudent withholding of antibiotic therapy does not appear to slow recovery
Immunocompromised patients may require therapy for 14 days.

Usual Adult Dose for Shigellosis

(Not approved by FDA)

400 mg orally every 12 hours for 5 days
Immunocompromised patients may require therapy for 7 to 10 days.

Usual Adult Dose for Traveler's Diarrhea

(Not approved by FDA)

400 mg orally every 12 hours for 3 days; however, most cases are self-limiting and prudent withholding of antibiotic therapy does not appear to slow recovery
Immunocompromised patients may require therapy for 7 to 14 days.

Renal Dose Adjustments

CrCl 30 mL/min or less: 400 mg orally once a day

Liver Dose Adjustments

No adjustment recommended.

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Data not available

Other Comments

The manufacturer's Medication Guide should be dispensed with each new and refill prescription.

Norfloxacin should be taken at least 1 hour before or at least 2 hours after a meal, milk, and/or other dairy products. Patients should be advised to drink plenty of fluids.

Iron-, zinc-, aluminum-, or magnesium-containing compounds (e.g., antacids, sucralfate, mineral supplements, buffered didanosine) should be administered either 2 hours before or 2 hours after norfloxacin.

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