Mesoridazine Dosage

Applies to the following strengths: 10 mg; 25 mg; 50 mg; 100 mg; 25 mg/mL

Usual Adult Dose for:

Schizophrenia

Additional dosage information:

Dose Adjustments
Precautions
Other Comments

Usual Adult Dose for Schizophrenia

Oral:
Initial dose: 50 mg three times a day (for most patients, regardless of severity)

Maintenance dose: 100 to 400 mg/day in divided doses.

Intramuscular:
Initial dose: 25 mg; may repeat in 30 to 60 minutes, if necessary.

Maintenance dose: 25 to 200 mg/day.

Dose Adjustments

The dosage of mesoridazine should be adjusted to the needs of the individual. The lowest effective dosage should always be used. When maximum response is achieved, dosage may be reduced gradually to a maintenance dose.

Precautions

Mesoridazine can cause dose-related prolongation of the QTc interval, which is associated with potentially life-threatening ventricular arrhythmias and sudden death. Mesoridazine should be avoided in combination with other drugs that are known to prolong the QTc interval and in patients with congenital long QT syndrome or a history of cardiac arrhythmias. Its use should be reserved for patients who fail to respond adequately to treatment with other antipsychotic drugs.

Mesoridazine is contraindicated in severe central nervous system depression or comatose states from any cause.

Other Comments

Mesoridazine has not been systematically evaluated in controlled trials for the treatment of patients with refractory schizophrenia and its efficacy in such patients is unknown.