Mecasermin Dosage

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Usual Pediatric Dose for:

Additional dosage information:

Usual Pediatric Dose for Primary IGF-1 Deficiency

Growth failure in children with severe primary Insulin-like Growth Factor-1 deficiency or with growth hormone gene deletion who have developed neutralizing antibodies to growth hormone.

2 years old to adult (closed epiphyses):
initial dose: 0.04 to 0.08 mg/kg twice daily by subcutaneous injection. If well tolerated for at least one week, the dose may be increased by 0.04 mg/kg per dose to the maximum of 0.12 mg/kg given twice daily. Dose should be administered shortly before or after (+/- 20 minutes) a meal or snack. If the patient is unable to eat shortly before or after a dose for any reason, that dose should be withheld. Subsequent doses should never be increased to make up for one or more missed doses.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Mecasermin contains benzyl alcohol as a preservative. Benzyl alcohol as a preservative has been associated with neurologic toxicity in neonates.

Dialysis

Data not available

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