Loteprednol / Tobramycin Ophthalmic Dosage

This dosage information may not include all the information needed to use Loteprednol / Tobramycin Ophthalmic safely and effectively. See additional information for Loteprednol / Tobramycin Ophthalmic.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Uveitis

1 to 2 drops instilled in conjunctival sac of affected eye(s) every 4 to 6 hours

During the initial 24 to 48 hours of treatment, the frequency may be increased to every 1 to 2 hours. As clinical signs improve, the frequency may be decreased gradually. Therapy should not be stopped prematurely.

Approved indication: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

Usual Adult Dose for Iritis

1 to 2 drops instilled in conjunctival sac of affected eye(s) every 4 to 6 hours

During the initial 24 to 48 hours of treatment, the frequency may be increased to every 1 to 2 hours. As clinical signs improve, the frequency may be decreased gradually. Therapy should not be stopped prematurely.

Approved indication: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

Usual Adult Dose for Bacterial Conjunctivitis

1 to 2 drops instilled in conjunctival sac of affected eye(s) every 4 to 6 hours

During the initial 24 to 48 hours of treatment, the frequency may be increased to every 1 to 2 hours. As clinical signs improve, the frequency may be decreased gradually. Therapy should not be stopped prematurely.

Approved indication: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

Usual Adult Dose for Keratitis

1 to 2 drops instilled in conjunctival sac of affected eye(s) every 4 to 6 hours

During the initial 24 to 48 hours of treatment, the frequency may be increased to every 1 to 2 hours. As clinical signs improve, the frequency may be decreased gradually. Therapy should not be stopped prematurely.

Approved indication: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

Usual Adult Dose for Cyclitis

1 to 2 drops instilled in conjunctival sac of affected eye(s) every 4 to 6 hours

During the initial 24 to 48 hours of treatment, the frequency may be increased to every 1 to 2 hours. As clinical signs improve, the frequency may be decreased gradually. Therapy should not be stopped prematurely.

Approved indication: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Loteprednol-tobramycin ophthalmic is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures.

Caution is recommended when used with glaucoma. Intraocular pressure should be monitored if used for 10 days or longer.

Patients should be examined (e.g., slit lamp biomicroscopy and, if appropriate, fluorescein staining) prior to initial and renewed prescription orders. No more than 20 mL should be prescribed initially and the prescription should not be refilled without further evaluation.

In acute purulent eye conditions, loteprednol-tobramycin ophthalmic may mask infection or enhance existing infection. Patients should be reevaluated if signs and symptoms do not improve after 2 days.

Extreme caution is recommended when treating patients with history of herpes simplex. Ocular steroid use may prolong the course and exacerbate the severity of many ocular viral infections.

If hypersensitivity occurs with loteprednol-tobramycin ophthalmic, use should be discontinued and appropriate therapy started.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Fungus invasion should be considered with any persistent corneal ulceration. Fungal cultures are recommended when appropriate.

Soft contact lenses should not be worn during use of loteprednol-tobramycin ophthalmic.

Patients should be instructed to avoid allowing the dropper tip to contact the eye, eyelid, fingers, or any other surface.

Hide
(web5)