Levamisole Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Malignant Disease

50 mg orally every 8 hours for 3 days (starting 7-30 days post-surgery). May be given as maintenance therapy for 3 days at 2 week intervals for 1 year.

Dose Adjustments

The dosage may depend upon the specific indication for use. Reference to specific protocols is recommended.

Precautions

If the WBC count is 2,500-3,500/mm³, defer the fluorouracil dose until the WBC count is > 3,500/mm³. If the WBC count is < 2,500/mm³, defer the fluorouracil dose until the WBC count is > 3,500/mm³ and resume the fluorouracil dose reduced by 20%. If the WBC count remains < 2,500/mm³ for over 10 days, despite deferring fluorouracil, discontinue administration of levamisole. Both drugs should be deferred when the platelet count is < 100,000/mm³.

Other Comments

Levamisole is indicated as adjuvant treatment in combination with fluorouracil after surgical resection for Duke's stage C colon cancer. On the first day of combination therapy, a CBC with differential and platelets, serum electrolytes, and liver function tests are recommended. Thereafter, a weekly CBC with differential and platelets prior to each treatment with fluorouracil is recommended. Serum electrolytes and liver function tests are recommended every 3 months for a total of 1 year. The patient should be informed that if flu-like symptoms, malaise, severe stomatitis and/or diarrhea occur, the physician should be notified immediately.

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