Human Papillomavirus Vaccine Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Human Papillomavirus Prophylaxis

Gardasil - women and men:
Cervical, vulvar, vaginal, and anal cancer caused by HPV and genital warts (condyloma acuminata) caused by HPV:
9 years through 26 years: one dose (0.5 mL) intramuscularly once. Repeat dose in 2 months and 6 months for a total of 3 doses.
Cervarix - women:
9 years through 25 years: one dose (0.5 mL) intramuscularly at 0 , 1, and 6 months.

Usual Pediatric Dose for Human Papillomavirus Prophylaxis

Gardasil - girls and boys:
9 years or older: one dose (0.5 mL) intramuscularly once. Repeat dose in 2 months and 6 months for a total of 3 doses.
Cervarix - girls:
9 years or older: one dose (0.5 mL) intramuscularly at 0 , 1, and 6 months.

Vaccine is usually initiated at 11 to 12 years old; optimally, vaccination should be completed prior to onset of sexual activity.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Because vaccinees may develop syncope, sometimes resulting in falling with injury, observation for 15 minutes after administration is recommended. Syncope, sometimes associated with tonic-clonic movements and other seizure like activity, has been reported following vaccination with human papillomavirus vaccine. When syncope is associated with tonic-clonic movements, the activity is usually transient and typically responds to restoring cerebral perfusion by maintaining a supine or Trendelenburg position.

Dialysis

Data not available

Other Comments

Minimum interval between the first and second dose of vaccine is 4 weeks; minimum interval between the second and third dose of vaccine is 12 weeks, minimum interval between first and third dose of the vaccine is 24 weeks.

If the vaccine series is interrupted and only one dose was given, administer the second dose as soon as possible and give the third dose at least 12 weeks later. If the vaccine series is interrupted and the first two doses were given, administer the third dose as soon as possible. Inadequate doses or doses received following a shorter than recommended dosing interval should be repeated. The HPV vaccine series should be completed with the same product whenever possible.

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