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Generic Name: human papillomavirus (HPV) vaccine, quadrivalent (HYOO man pap il OH ma VI rus vax EEN, kwa dri VAY lent)
Brand Names: Gardasil

What is Gardasil?

Gardasil (HPV quadrivalent vaccine) and Gardasil 9 (HPV 9-valent vaccine) are used in both females and males. Another form of HPV vaccine (Cervarix) is used only in females. This medication guide provides information only for Gardasil (HPV quadrivalent vaccine).

Human papillomavirus (HPV) can cause genital warts, cancer of the cervix, anal cancer, and various cancers of the vulva or vagina.

Gardasil is used in girls and young women ages 9 through 26 to prevent cervical/vaginal/anal cancers caused by certain types of HPV.

Gardasil is also used in boys and young men ages 9 through 26 to prevent anal cancer or genital warts caused by certain types of HPV.

You may receive Gardasil even if you have already had genital warts, or had a positive HPV test or abnormal pap smear in the past. However, this vaccine will not treat active genital warts or HPV-related cancers, and it will not cure HPV infection.

Gardasil only prevents diseases caused by HPV types 6, 11, 16, and 18. It will not prevent diseases caused by other types of HPV.

The Centers for Disease Control and Prevention (CDC) recommends HPV vaccine for all boys and girls ages 11 or 12 years old. The vaccine is also recommended in teenage boys and girls who have not already received the vaccine or have not completed all booster shots.

Like any vaccine, the Gardasil may not provide protection from disease in every person.

Important information

You should not receive a booster vaccine if you have had a life-threatening allergic reaction after the first shot.

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You may feel faint during the first 15 minutes after receiving Gardasil. Some people have had seizure-like reactions after receiving this vaccine.

Before receiving Gardasil

You should not receive a booster vaccine if you have had a life-threatening allergic reaction after the first shot.

To make sure Gardasil is safe for you, tell your doctor if you have:

  • a fever;

  • a weak immune system;

  • an allergy to yeast; or

  • if you are being treated with cancer medicine, steroids, or other drugs that can weaken your immune system.

Gardasil is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether HPV vaccine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Gardasil will not protect against sexually transmitted diseases such as chlamydia, gonorrhea, herpes, HIV, syphilis, and trichomoniasis.

How is human papillomavirus vaccine given?

Gardasil is given as an injection (shot) into a muscle in your upper arm or thigh. You will receive this injection in a doctor's office or other clinic setting.

Gardasil is given in a series of 3 shots. You may have the first shot at any time as long as you are between the ages of 9 and 26 years old. Then you will need to receive a second dose 2 months after your first shot, and a third dose 6 months after your first shot.

Be sure you receive all recommended doses of Gardasil. If you do not receive the full series of vaccines, you may not be fully protected against the disease.

A Gardasil vaccination should not be used in place of having a routine pelvic exam, Pap smear, or anal exam to screen for cervical or anal cancer.

What happens if I miss a dose?

Contact your doctor if you will miss a booster dose or if you get behind schedule. The next dose should be given as soon as possible. There is no need to start over.

What happens if I overdose?

An overdose of Gardasil is unlikely to occur.

What should I avoid while receiving human papillomavirus vaccine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Human papillomavirus vaccine side effects

Get emergency medical help if you have signs of an allergic reaction to Gardasil: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Keep track of any and all side effects you have after receiving Gardasil. When you receive a booster dose, you will need to tell the doctor if the previous shot caused any side effects.

You may feel faint after receiving Gardasil. Some people have had seizure-like reactions after receiving a human papilloma virus vaccine. Your doctor may want you to remain under observation during the first 15 minutes after the injection.

Developing cancer from HPV is much more dangerous to your health than receiving the vaccine to protect against it. However, like any medicine, Gardasil can cause side effects but the risk of serious side effects is extremely low.

Call your doctor at once if you have:

  • severe stomach pain;

  • fever, chills, swollen glands, general ill feeling;

  • easy bruising or bleeding, unusual weakness;

  • joint pain, muscle pain or weakness;

  • confusion, seizure (convulsions);

  • chest pain; or

  • feeling short of breath.

Common Gardasil side effects may include:

  • pain, swelling, bruising, redness, or itching where the shot was given;

  • nausea, vomiting;

  • headache, dizziness; or

  • fever.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

See also: Side effects (in more detail)

What other drugs will affect human papillomavirus vaccine?

Other drugs may interact with HPV quadrivalent vaccine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Gardasil. Additional information is available from your local health department or the Centers for Disease Control and Prevention.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Gardasil only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2015 Cerner Multum, Inc. Version: 8.02. Revision Date: 2015-09-01, 5:26:22 PM.