Generic name: hetastarch in sodium chloride
Dosage form: injection, solution
This dosage information does not include all the information needed to use Hespan safely and effectively. See full prescribing information for Hespan.
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Dosage for Acute Use in Plasma Volume Expansion
HESPAN® is administered by intravenous infusion only. Total dosage and rate of infusion depend upon the amount of blood or plasma lost and the resultant hemoconcentration.
The amount usually administered is 500 to 1000 mL. Doses of more than 1500 mL per day for the typical 70 kg patient (approximately 20 mL per kg of body weight) are usually not required although higher doses have been reported in postoperative and trauma patients where severe blood loss has occurred (see WARNINGS and PRECAUTIONS).
Dosage in Leukapheresis
250 to 700 mL of HESPAN® (6% hetastarch in 0.9% sodium chloride injection) to which citrate anticoagulant has been added is typically administered by aseptic addition to the input line of the centrifugation apparatus at a ratio of 1:8 to 1:13 to venous whole blood. The HESPAN® and citrate should be thoroughly mixed to assure effective anticoagulation of blood as it flows through the leukapheresis machine.
When stored at room temperature, HESPAN® admixtures of 500–560 mL with citrate concentrations up to 2.5% were compatible for 24 hours. The safety and compatibility of additives other than citrate have not been established.
Do not use plastic container in series connection.
If administration is controlled by a pumping device, care must be taken to discontinue pumping action before the container runs dry or air embolism may result. If administration is not controlled by a pumping device, refrain from applying excessive pressure (>300mmHg) causing distortion to the container such as wringing or twisting. Such handling could result in breakage of the container.
This solution is intended for intravenous administration using sterile equipment. It is recommended that intravenous administration apparatus be replaced at least once every 24 hours.
Use only if solution is clear and container and seals are intact.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
If administration is by pressure infusion, all air should be withdrawn or expelled from the bag through the medication port prior to infusion.
The safety and compatibility of other additives have not been established.