Ganciclovir Ophthalmic Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for CMV Retinitis

1 surgical implant in the posterior segment of the affected eye(s) every 5 to 8 months. Following depletion of ganciclovir from the implant, as evidenced by progression of retinitis, the implant may be removed and replaced.

Usual Adult Dose for Herpes Simplex Dendritic Keratitis

1 drop in the affected eye 5 times per day (approximately every 3 hours while awake) until the corneal ulcer heals, and then 1 drop 3 times per day for 7 days.

Usual Pediatric Dose for CMV Retinitis

Less than 9 years: Safety and efficacy have not been established.
9 years or older: 1 surgical implant in the posterior segment of the affected eye(s) every 5 to 8 months. Following depletion of ganciclovir from the implant, as evidenced by progression of retinitis, the implant may be removed and replaced.

Usual Pediatric Dose for Herpes Simplex Dendritic Keratitis

2 years or older:
1 drop in the affected eye 5 times per day (approximately every 3 hours while awake) until the corneal ulcer heals, and then 1 drop 3 times per day for 7 days.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

The replacement implant may be inserted at the previous site or at a completely new site. Depending on the thickness and integrity of the sclera, one group of experts suggests using a new site after the second implant to minimize wound complications.

Patients should not wear contact lenses if they have signs or symptoms of herpetic keratitis or during the course of therapy with ganciclovir ophthalmic gel.

Dialysis

Data not available

Other Comments

4.5 to 6.4 mg are released gradually over 5 to 8 months. Once the supply of ganciclovir is depleted, the implant should be removed and replaced. Depletion is presumed when there is progression of previously controlled retinitis.

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