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Forane Dosage

Generic name: ISOFLURANE 1mL in 1mL
Dosage form: inhalant
Drug class: General anesthetics

Medically reviewed by Drugs.com. Last updated on Nov 1, 2022.

Isoflurane should be administered only by persons trained in the administration of general anesthesia.

Facilities for maintenance of a patent airway, artificial ventilation, oxygen enrichment, and circulatory resuscitation must be immediately available.

Isoflurane is administered by inhalation. Isoflurane should be delivered from a vaporizer specifically designed for use with isoflurane.

The minimum alveolar concentration (MAC) of isoflurane decreases with increasing patient age.

Dosage for induction and maintenance must be individualized and titrated to the desired effect according to the patient’s age and clinical status.

Premedication:

Premedication should be selected according to the need of the individual patient, taking into account that secretions are weakly stimulated by FORANE, and the heart rate tends to be increased.

Induction:

Induction with isoflurane in oxygen or in combination with oxygen-nitrous oxide mixtures may produce coughing, breath holding, laryngospasm and bronchospasm, which increases with the concentration of isoflurane. These difficulties may be avoided by the use of a hypnotic dose of an ultra-short-acting barbiturate. Inspired concentrations of 1.5 to 3.0% isoflurane usually produce surgical anesthesia in 7 to 10 minutes.

Maintenance:

Isoflurane MAC values according to age are shown below:

Age

Average MAC Value

In 100% Oxygen

Average MAC Value

In 30% Oxygen and 70% N2 O

Preterm neonates ˂32 weeks gestational age

1.28%

Preterm neonates 32-37 weeks gestational age

1.41%

0-1 month

1.60%

1-6 months

1.87%

6-12 months

1.80%

1-5 years

1.60%

6-10 years

1.45%

11-18 years

1.38%

19-30 years

1.28%

0.56%

31-55 years

1.15%

0.50%

55-83 years

1.05%

0.37%

Dosage for induction and maintenance must be individualized and titrated to the desired effect according to the patient’s age and clinical status.

Surgical levels of anesthesia may be sustained with a 1.0 to 2.5% concentration when nitrous oxide is used concomitantly. An additional 0.5 to 1.0% may be required when isoflurane is given using oxygen alone. If added relaxation is required, supplemental doses of muscle relaxants may be used.

The level of blood pressure during maintenance is an inverse function of isoflurane concentration in the absence of other complicating problems. Excessive decreases may be due to depth of anesthesia and in such instances may be corrected by lightening anesthesia.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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