Entereg Dosage

Generic name: alvimopan
Dosage form: capsule

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Dosage in Adults

For hospital use only. The recommended adult dosage of ENTEREG is 12 mg administered 30 minutes to 5 hours prior to surgery followed by 12 mg twice daily beginning the day after surgery for a maximum of 7 days or until discharge. Patients should not receive more than 15 doses of ENTEREG.

Special Populations

Geriatric Use:  No dosage adjustment is necessary in elderly patients [see Use in Specific Populations (8.5)].

Hepatic Impairment:  No dosage adjustment is necessary in patients with mild-to-moderate hepatic impairment (Child-Pugh Class A and B). ENTEREG is not recommended for use in patients with severe hepatic impairment (Child-Pugh Class C) [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)].

Renal Impairment:  No dosage adjustment is necessary in patients with mild-to-severe renal impairment, but they should be monitored for adverse effects.  ENTEREG is not recommended for use in patients with end-stage renal disease [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)].

Race: No dosage adjustment is necessary in Black, Hispanic and Japanese patients,
however, due to observed 2-fold greater ENTEREG plasma concentrations in healthy male
Japanese subjects, Japanese patients should be monitored for possible adverse effects. [see Use
in
Specific Populations (8.8) and Clinical Pharmacology (12.3)]

Hide
(web4)