Beractant Dosage

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Usual Pediatric Dose for:

Additional dosage information:

Usual Pediatric Dose for Respiratory Distress Syndrome

<48 hours of life: 4 mL/kg instilled intratracheally no more often than every 6 hours for a total of up to 4 doses. For prevention of respiratory distress syndrome in premature infants with birth weights of less than 1750 g and more than 600 g, the first dose is preferably given within 15 minutes of birth. For rescue treatment, the first dose is given as soon as possible, preferably within 8 hours of birth.
>48 hours of life: Safety and efficacy have not been established.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy in neonates with birth weights <600 g or >1750 g have not been established.

Dialysis

Data not available

Other Comments

The dose is administered in 4 portions of 1 mL/kg each over 2 to 3 seconds each through a 5-French end hole catheter inserted into the endotracheal tube. After each quarter-dose, the catheter should be removed and the infant ventilated for at least 30 seconds or until stable. The infant is then repositioned for the next quarter-dose. The infant should not be suctioned for 1 hour after dosing unless there are signs of significant airway obstruction.

Additional doses of 4 mL/kg may be given at least 6 hours apart if there is evidence of continuing respiratory distress (the infant is still intubated and requires at least 30% inspired oxygen to maintain a PaO2 <=80 torr, or RDS has been confirmed radiographically in infants who had received a prevention dose). Ventilator settings may require adjustment for repeat doses. Manual bag ventilation should not be used to administer repeat doses.

Heart rate, transcutaneous O2 saturation, and ABGs should be closely monitored.

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