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Tafenoquine Disease Interactions

There are 3 disease interactions with tafenoquine.

Major

Tafenoquine (applies to tafenoquine) G6PD deficiency

Major Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency

Tafenoquine is contraindicated in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency or unknown G6PD status due to the risk of hemolytic anemia. All patients must be tested for G6PD deficiency prior to prescribing tafenoquine.

References

  1. (2018) "Product Information. Arakoda (tafenoquine)." 60 Degrees Pharmaceuticals LLC
Major

Tafenoquine (applies to tafenoquine) psychotic disorders

Major Potential Hazard, Moderate plausibility. Applicable conditions: Psychosis

Tafenoquine is contraindicated in patients with a history of psychotic disorders or current psychotic symptoms such as hallucinations, delusions, and/or grossly disorganized behavior. If psychotic symptoms occur (hallucinations, delusions), consider discontinuation of tafenoquine and a prompt evaluation by a mental health professional as soon as possible. Other psychiatric symptoms, such as changes in mood, anxiety, insomnia, and nightmares, should be promptly evaluated by a medical professional if they are moderate and last more than three days or are severe.

References

  1. (2018) "Product Information. Arakoda (tafenoquine)." 60 Degrees Pharmaceuticals LLC
Moderate

Tafenoquine (applies to tafenoquine) hepatic/renal

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease

The pharmacokinetics of tafenoquine have not been studied in patients with renal or hepatic impairment. If tafenoquine is administered to such patients, close monitoring for adverse reactions is needed.

References

  1. (2018) "Product Information. Arakoda (tafenoquine)." 60 Degrees Pharmaceuticals LLC

Tafenoquine drug interactions

There are 35 drug interactions with tafenoquine.

Tafenoquine alcohol/food interactions

There is 1 alcohol/food interaction with tafenoquine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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