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Sonidegib Disease Interactions

There are 2 disease interactions with sonidegib.

Moderate

Hedgehog pathway inhibitors (applies to sonidegib) musculoskeletal disorders

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: History - Musculoskeletal Disorder

Musculoskeletal adverse reactions, which may be accompanied by serum creatine kinase elevations have been reported with the use of drugs that inhibit the hedgehog pathway. It is recommended to obtain serum creatine kinase levels and renal function tests prior to initiating therapy, periodically during treatment, and as clinically indicated. Care should be taken when prescribing these agents to patients presenting musculoskeletal pain or myalgia. Temporary dose interruption or discontinuation of therapy may be required based on the severity of musculoskeletal adverse reactions.

References

  1. (2015) "Product Information. Odomzo (sonidegib)." Novartis Pharmaceuticals
Moderate

Sonidegib (applies to sonidegib) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Mild (CrCl 60 to 89 mL/min) and moderate (CrCl 30 to 59 mL/min) renal impairment had no effect on sonidegib steady-state exposure. Caution is recommended when this agent is administered to patients with severe renal impairment as no data is available from the manufacturer.

References

  1. (2015) "Product Information. Odomzo (sonidegib)." Novartis Pharmaceuticals

Sonidegib drug interactions

There are 172 drug interactions with sonidegib.

Sonidegib alcohol/food interactions

There is 1 alcohol/food interaction with sonidegib.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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