Pheburane Disease Interactions
There are 3 disease interactions with Pheburane (sodium phenylbutyrate).
Sodium phenylbutyrate (applies to Pheburane) fluid retention
Major Potential Hazard, High plausibility. Applicable conditions: Congestive Heart Failure, Renal Dysfunction
The use of sodium phenylbutyrate may cause fluid retention in patients with congestive heart failure, renal dysfunction, or sodium retention with edema. Sodium phenylbutyrate is primarily excreted by the kidney and these patients may exhibit reduced excretion. Therapy with sodium phenylbutyrate should be administered cautiously in these patients. Monitoring plasma levels of ammonia, arginine, branched-chain amino acids and serum proteins to maintain within normal limits and glutamine to less than 1000 mcmol/L is recommended.
Sodium phenylbutyrate (applies to Pheburane) liver/kidney disease
Moderate Potential Hazard, High plausibility. Applicable conditions: Liver Disease, Renal Dysfunction
Sodium phenylbutyrate is primarily metabolized in the liver and kidney. Therapy with sodium phenylbutyrate should be administered cautiously in patients with liver disease. Monitoring plasma levels of ammonia, arginine, branched-chain amino acids and serum proteins to maintain within normal limits and glutamine to less than 1000 mcmol/L is recommended.
Sodium phenylbutyrate (applies to Pheburane) neurotoxicity
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: CNS Disorder, Myoneural Disorder, Peripheral Neuropathy
Sodium phenylbutyrate is a pro-drug and is rapidly metabolized to the active, phenylacetate. Neurotoxicity, including exacerbation of a preexisting neuropathy, has been reported with the use of intravenous phenylacetate. The acute onset and reversibility when the phenylacetate infusion was discontinued suggested a drug effect. Care should be exercised when prescribing sodium phenylbutyrate to patients at risk for neurotoxicity.
Pheburane drug interactions
There are 31 drug interactions with Pheburane (sodium phenylbutyrate).
Pheburane alcohol/food interactions
There is 1 alcohol/food interaction with Pheburane (sodium phenylbutyrate).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.