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Nplate Disease Interactions

There are 3 disease interactions with Nplate (romiplostim).

Major

Romiplostim (applies to Nplate) leukemia

Major Potential Hazard, Moderate plausibility. Applicable conditions: Myelodysplastic Disease

Progression from myelodysplastic syndromes (MDS) to acute myelogenous leukemia (AML) has been observed in clinical trials with romiplostim. This drug is not indicated for the treatment of thrombocytopenia due to MDS or any other cause other than chronic ITP.

References

  1. (2008) "Product Information. Nplate (romiplostim)." Amgen USA
Moderate

Romiplostim (applies to Nplate) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

No clinical studies with romiplostim have been conducted in patients with hepatic impairment.

References

  1. (2008) "Product Information. Nplate (romiplostim)." Amgen USA
Moderate

Romiplostim (applies to Nplate) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

No clinical studies with romiplostim have been conducted in patients with renal impairment.

References

  1. (2008) "Product Information. Nplate (romiplostim)." Amgen USA

Nplate drug interactions

There are 9 drug interactions with Nplate (romiplostim).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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