Phentolamine Disease Interactions
There are 3 disease interactions with phentolamine.
Phentolamine (applies to phentolamine) cardiovascular dysfunction
Major Potential Hazard, High plausibility. Applicable conditions: Ischemic Heart Disease, Arrhythmias
The use of phentolamine is contraindicated in patients with myocardial infarction, or a history of myocardial infarction, coronary artery disease or insufficiency, or angina. Hypotension due to decreased peripheral vascular resistance results from direct relaxation of vascular smooth muscle and/or alpha adrenergic blockade. Heart rate and cardiac output are increased due to beta adrenergic agonist properties. Acute and prolonged hypotensive episodes with reflex tachycardia and arrhythmia have also occurred during phentolamine therapy.
Phentolamine (applies to phentolamine) cerebrovascular disorders
Moderate Potential Hazard, High plausibility. Applicable conditions: Cerebral Vascular Disorder
Cerebrovascular spasms and occlusions have occurred as a result of marked hypotension during phentolamine therapy. Therapy with phentolamine should be administered cautiously in patients with or a history of cerebrovascular disorders.
Phentolamine (applies to phentolamine) hepatic/renal dysfunction
Moderate Potential Hazard, Low plausibility. Applicable conditions: Liver Disease
The pharmacokinetic disposition of phentolamine has not been fully determined. Limited data suggest that phentolamine is metabolized by the liver. Phentolamine is eliminated by the kidney and approximately 13% is excreted unchanged in the urine. Therapy with phentolamine should be administered cautiously in patients with severe liver and/or renal function. Clinical monitoring of hepatic and/or renal function is recommended.
Phentolamine drug interactions
There are 218 drug interactions with phentolamine.
Phentolamine alcohol/food interactions
There is 1 alcohol/food interaction with phentolamine.
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- Drug class: miscellaneous cardiovascular agents
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.