Maxolon (metoclopramide) Disease Interactions

There are 10 disease interactions with Maxolon (metoclopramide):

Metoclopramide (Includes Maxolon) ↔ Depression

Severe Potential Hazard, Moderate plausibility

Applies to: Depression

Metoclopramide has been reported to cause mental depression in patients with and without a prior history of depression. Symptoms have ranged from mild to severe and have included suicidal ideation and suicide. Therapy with metoclopramide should be administered cautiously, and only if benefits are anticipated to outweigh the potential risks, in patients with a history of mental depression, especially suicidal tendencies. Some patients who experience depression with metoclopramide have improved following temporary discontinuation of the drug and reinstitution at a lower dosage with gradual titration.

References

  1. "Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  2. Bottner RK, Tullio CJ "Metoclopramide and depression." Ann Intern Med 103 (1985): 482
  3. Feder R "Metoclopramide and depression." J Clin Psychiatry 48 (1987): 38
View all 5 references

Metoclopramide (Includes Maxolon) ↔ Gastrointestinal Disorders

Severe Potential Hazard, High plausibility

Applies to: Gastrointestinal Hemorrhage, Gastrointestinal Perforation, Intestinal Obstruction

The use of metoclopramide is contraindicated in patients with conditions where stimulation of gastrointestinal motility might be harmful, such as mechanical bowel obstruction, bowel perforation, or gastrointestinal hemorrhage.

References

  1. "Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

Metoclopramide (Includes Maxolon) ↔ Nms

Severe Potential Hazard, Moderate plausibility

Applies to: Neuroleptic Malignant Syndrome

Although not a neuroleptic agent, metoclopramide has antidopaminergic effects and may rarely precipitate or aggravate a potentially fatal symptom complex known as Neuroleptic Malignant Syndrome (NMS). Clinical manifestations of NMS include hyperpyrexia, muscle rigidity, involuntary movements, altered mental status and autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac arrhythmias). Metoclopramide therapy should not be initiated in patients with active NMS and should be immediately discontinued if currently being administered in such patients. In patients with a history of NMS, introduction or reintroduction of metoclopramide or other antidopaminergic therapy should be carefully considered, since NMS may recur.

References

  1. Donnet A, Harle JR, Dumont JC, Alif Cherif A "Neuroleptic malignant syndrome induced by metoclopramide." Biomed Pharmacother 45 (1991): 461-2
  2. Friedman LS, Weinrauch LA, D'Elia JA "Metoclopramide-induced neuroleptic malignant syndrome." Arch Intern Med 147 (1987): 1495-7
  3. Patterson JF "Neuroleptic malignant syndrome associated with metoclopramide." South Med J 81 (1988): 674-5
View all 11 references

Metoclopramide (Includes Maxolon) ↔ Pheochromocytoma

Severe Potential Hazard, High plausibility

Applies to: Pheochromocytoma

The use of metoclopramide is contraindicated in patients with pheochromocytoma. In a study involving patients with essential hypertension, intravenously administered metoclopramide was shown to induce the release of catecholamines. Hypertensive crises may occur in patients with pheochromocytoma due to induction of catecholamine release from the tumor.

References

  1. Agabiti-Rosei E, Aliccandri CL, Corea L "Hyperstensive crisis in patients with phaeochromocytoma given metoclopramide." Lancet 1 (1977): 600
  2. Abe M, Orita Y, Nakashima Y, Nakamura M "Hypertensive crisis induced by metoclopramide in patient with pheochromocytoma." Angiology 35 (1984): 122-8
  3. "Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
View all 5 references

Metoclopramide (Includes Maxolon) ↔ Seizures

Severe Potential Hazard, High plausibility

Applies to: Seizures

The use of metoclopramide is contraindicated in patients with seizure disorders. Metoclopramide may increase the frequency and severity of seizures.

References

  1. Desmond PV, Watson KJ "Metoclopramide--a review." Med J Aust 144 (1986): 366-9
  2. "Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

Metoclopramide (Includes Maxolon) ↔ Tardive Dyskinesia

Severe Potential Hazard, Moderate plausibility

Applies to: Tardive Dyskinesia

Metoclopramide may precipitate symptoms of tardive dyskinesia (TD), a syndrome consisting of rhythmic involuntary movements variously involving the tongue, face, mouth, lips, jaw, and/or trunk and extremities, following chronic use of at least several months but often years. Elderly patients, particularly women, are most susceptible. Both the risk of developing TD and the likelihood that it will become irreversible increase with the duration and total cumulative dose of metoclopramide or other antidopaminergic therapy administered. However, patients may infrequently develop symptoms after relatively brief treatment periods at low dosages. If TD occurs during metoclopramide therapy, prompt withdrawal of the drug or at least a lowering of the dosage should be considered. TD symptoms usually become more severe after drug discontinuation or a dosage reduction, but may gradually improve over months to years. In patients with preexisting drug-induced TD, initiating or increasing the dosage of metoclopramide therapy may temporarily mask the symptoms of TD but may eventually worsen the condition.

References

  1. JimenezJimenez FJ, GarciaRuiz PJ, Molina JA "Drug-induced movement disorders." Drug Saf 16 (1997): 180-204
  2. Bateman DN, Rawlins MD, Simpson JM "Extrapyramidal reactions with metoclopramide." Br Med J (Clin Res Ed) 291 (1985): 930-2
  3. Putnam PE, Orenstein SR, Wessel HB, Stowe RM "Tardive dyskinesia associated with use of metoclopramide in a child." J Pediatr 121 (1992): 983-5
View all 10 references

Metoclopramide (Includes Maxolon) ↔ Fluid Retention

Moderate Potential Hazard, Moderate plausibility

Applies to: Congestive Heart Failure, Fluid Retention, Cirrhosis

Metoclopramide produces a transient increase in plasma aldosterone and may cause fluid retention and volume overload in susceptible patients. Therapy with metoclopramide should be administered cautiously in patients with or at risk for fluid overload (e.g., cirrhosis, congestive heart failure). If it occurs within the first few weeks of metoclopramide therapy, the drug should be discontinued.

References

  1. "Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  2. Ahmad S "Metoclopramide-induced acute congestive heart failure." South Med J 84 (1991): 283-4

Metoclopramide (Includes Maxolon) ↔ Hypertension

Moderate Potential Hazard, Moderate plausibility

Applies to: Hypertension

In a study involving patients with essential hypertension, intravenously administered metoclopramide was shown to induce the release of catecholamines. Therapy with metoclopramide should be administered cautiously in patients with hypertension because of potential increases in blood pressure.

References

  1. Filibeck DJ, Grimm D, Forman WB, Leidner BA "Metoclopramide-induced hypertensive crisis." Clin Pharm 3 (1984): 548-9
  2. "Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

Metoclopramide (Includes Maxolon) ↔ Parkinsonism

Moderate Potential Hazard, Moderate plausibility

Applies to: Parkinsonism

Metoclopramide has antidopaminergic effects and may cause pseudo-parkinsonian symptoms such as akinesia, bradykinesia, tremors, pill-rolling motion, cogwheel rigidity, and postural abnormalities including stooped posture and shuffling gait. The onset is usually within the first six months following initiation of therapy but occasionally after longer periods. Symptoms generally subside within 2 to 3 months after drug discontinuation. Therapy with metoclopramide should be administered cautiously, if at all, in patients with Parkinson's disease or parkinsonian symptoms.

References

  1. "Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  2. Miller LG, Jankovic J "Metoclopramide-induced movement disorders. Clinical findings with a review of the literature." Arch Intern Med 149 (1989): 2486-92
  3. JimenezJimenez FJ, GarciaRuiz PJ, Molina JA "Drug-induced movement disorders." Drug Saf 16 (1997): 180-204
View all 7 references

Metoclopramide (Includes Maxolon) ↔ Renal Dysfunction

Moderate Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Renal function affects the clearance of metoclopramide. In patients with varying degrees of renal impairment, a reduction in creatinine clearance was correlated with a reduction in plasma clearance, renal clearance and non-renal clearance, and increase in elimination half-life of metoclopramide. Therapy with metoclopramide should be administered cautiously in patients with impaired renal function. A dosage reduction may be appropriate to avoid drug accumulation.

References

  1. Lloveras J, Masramon J, Aubia J, Llorach M "Amiodarone, metoclopramide, and renal failure." Lancet 1 (1979): 981-2
  2. Bateman DN, Gokal R, Dodd TR, Blain PG "The pharmacokinetics of single doses of metoclopramide in renal failure." Eur J Clin Pharmacol 19 (1981): 437-41
  3. Caralps A "Metoclopramide and renal failure." Lancet 1 (1979): 554
View all 5 references

You should also know about...

Maxolon (metoclopramide) drug Interactions

There are 606 drug interactions with Maxolon (metoclopramide)

Maxolon (metoclopramide) alcohol/food Interactions

There are 2 alcohol/food interactions with Maxolon (metoclopramide)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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