Metoclopramide Dosage

This dosage information may not include all the information needed to use Metoclopramide safely and effectively. See additional information for Metoclopramide.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for Nausea/Vomiting

Postoperative nausea and vomiting:
Parenteral: 10 to 20 mg IM at or near the end of surgery

Usual Adult Dose for Gastroesophageal Reflux Disease

Oral: 10 to 15 mg up to 4 times a day 30 minutes before meals and at bedtime, depending upon symptoms being treated and clinical response. Therapy should not exceed 12 weeks.

Usual Adult Dose for Small Intestine Intubation

If the tube has not passed the pylorus with conventional methods in 10 minutes, a single (undiluted) dose may be administered IV slowly over 1 to 2 minutes:
Adults and pediatric patients greater than or equal to 14 years: 10 mg IV as a single dose administered over 1 to 2 minutes.

Usual Adult Dose for Radiographic Exam

Adults and pediatric patients greater than or equal to 14 years: 10 mg IV as a single dose administered over 1 to 2 minutes to facilitate gastric emptying where delayed gastric emptying interferes with radiological examination of the stomach and/or small intestine.

Usual Adult Dose for Gastroparesis

During the earliest manifestations of diabetic gastric stasis, oral administration may be initiated. If severe symptoms are present, therapy should begin with IM or IV administration for up to 10 days until symptoms subside at which time the patient can be switched to oral therapy. Since diabetic gastric stasis is often recurrent, therapy should be reinstituted at the earliest manifestation.

Parenteral: 10 mg 4 times daily, IV (slowly over a 1 to 2 minute period) or IM for up to 10 days.

Oral: 10 mg 4 times daily, 30 minutes before meals and at bedtime, for 2 to 8 weeks depending on clinical response.

Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced

IV infusion: 1 to 2 mg/kg/dose (depending on the emetogenic potential of the agent) IV (infused over a period of not less than 15 minutes) 30 minutes before administration of chemotherapy. The dose may be repeated twice at 2 hour intervals following the initial dose. If vomiting is still not suppressed, the same dose may be repeated 3 more times at 3 hour intervals.

For doses higher than 10 mg, the injection should be diluted in 50 mL of a parenteral solution. Normal saline is the preferred diluent.

If acute dystonic reactions occur, 50 mg of diphenhydramine hydrochloride may be injected IM.

Usual Adult Dose for Migraine

Use for treatment of migraine headaches is not an FDA approved indication; however, metoclopramide has shown efficacy in studies at a dose of 10 to 20 mg IV once (used in combination with analgesics or ergot derivatives).

Usual Pediatric Dose for Gastroesophageal Reflux Disease

Metoclopramide is not approved by the FDA for gastroesophageal reflux disease in pediatric patients; however, the following doses have been studied:

Oral, IM, IV:
Infants and Children: 0.4 to 0.8 mg/kg/day in 4 divided doses

Usual Pediatric Dose for Small Intestine Intubation

Metoclopramide IV is approved by the FDA for pediatric use to facilitate small bowel intubation by causing gastric emptying where delayed gastric emptying interferes with radiological examination of the stomach and/or small intestine.

If the tube has not passed the pylorus with conventional methods in 10 minutes, a single (undiluted) dose may be administered IV slowly over 1 to 2 minutes:

Less than 6 years: 0.1 mg/kg IV as a single dose

6 to 14 years: 2.5 to 5 mg IV as a single dose

Children greater than 14 years: 10 mg as a single dose

Usual Pediatric Dose for Nausea/Vomiting - Chemotherapy Induced

Metoclopramide is not approved by the FDA for chemotherapy induced nausea and vomiting in pediatric patients; however, the following doses have been studied:

IV:
1 to 2 mg/kg/dose IV every 30 minutes before chemotherapy and every 2 to 4 hours

Usual Pediatric Dose for Nausea/Vomiting - Postoperative

Metoclopramide is not approved by the FDA for postoperative nausea and vomiting in pediatric patients; however, the following doses have been studied:
IV:
Children less than or equal to 14 years: 0.1 to 0.2 mg/kg/dose (maximum dose: 10 mg/dose); repeat every 6 to 8 hours as needed
Children greater than 14 years and Adults: 10 mg; repeat every 6 to 8 hours as needed

Renal Dose Adjustments

CrCl less than 40 mL/min:
Initial dose: 50% of the usual recommended dose.
Subsequent dose adjustments should be made according to patient response and tolerability.

Liver Dose Adjustments

In patients with cirrhosis or jaundice, use the lowest recommended dosage because of decreased plasma clearance.

Dose Adjustments

5 mg per dose may be used in the elderly.

Precautions

Safety and effectiveness of metoclopramide oral tablets and oral disintegrating tablets have not been established in pediatric patients (less than 18 years of age). Safety and effectiveness of metoclopramide IV have not been established in pediatric patients (less than 18 years of age) except to facilitate small bowel intubation in pediatric patients above 14 years of age.

Dialysis

Metoclopramide is not dialyzable.

Other Comments

The maximum duration of therapy with metoclopramide should not exceed 12 weeks.

Metoclopramide probably does not provide pain relief in migraine headaches and for this reason is often used in combination with analgesics or ergot derivatives. Metoclopramide may be effective in migraine headaches due to its prokinetic properties and antiemetic effects.

Metoclopramide oral disintegrating tablets (ODT) disintegrates on the tongue in approximately one minute (with a range of 10 seconds to 14 minutes) and is designed to be taken without liquid; however, the effect on the pharmacokinetics of taking metoclopramide ODT with liquid is unknown.

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