Purinethol Disease Interactions
There are 5 disease interactions with Purinethol (mercaptopurine).
Antineoplastics (applies to Purinethol) infections
Major Potential Hazard, High plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral
Because of their cytotoxic effects on rapidly proliferating tissues, antineoplastic agents frequently can, to varying extent, induce myelosuppression. The use of these drugs may be contraindicated in patients with known infectious diseases. All patients should be instructed to immediately report any signs or symptoms suggesting infection such as fever, sore throat, or local infection during antineoplastic therapy. Close clinical monitoring of hematopoietic function is recommended.
References
- "Product Information. Methotrexate (methotrexate)." Lederle Laboratories PROD (2002):
- "Product Information. Platinol (cisplatin)." Bristol-Myers Squibb PROD (2001):
- "Product Information. Vepesid (etoposide)." Bristol-Myers Squibb PROD (2001):
- "Product Information. Novantrone (mitoxantrone)." Immunex Corporation PROD (2001):
- "Product Information. Mutamycin (mitomycin)." Bristol-Myers Squibb PROD (2001):
- "Product Information. Ifex (ifosfamide)." Bristol-Myers Squibb PROD (2001):
- "Product Information. Thiotepa (thiotepa)." Hikma USA (formerly West-Ward Pharmaceutical Corporation) PROD (2001):
- "Product Information. Fludara (fludarabine)." Berlex Laboratories PROD (2001):
- "Product Information. Idamycin (idarubicin)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Matulane (procarbazine)." Roche Laboratories PROD (2001):
- "Product Information. DTIC-Dome (dacarbazine)." Bayer PROD (2001):
- "Product Information. Adriamycin PFS (doxorubicin)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Leustatin (cladribine)." Ortho Biotech Inc PROD (2001):
- "Product Information. Gemzar (gemcitabine)." Lilly, Eli and Company PROD (2001):
- "Product Information. Hycamtin (topotecan)." SmithKline Beecham PROD (2001):
- "Product Information. Taxotere (docetaxel)." Rhone Poulenc Rorer PROD (2001):
- "Product Information. Taxol (paclitaxel)." Bristol-Myers Squibb PROD (2001):
- "Product Information. Nipent (pentostatin)." Hospira Inc PROD (2001):
- "Product Information. Tabloid (thioguanine)." Prasco Laboratories PROD (2001):
- "Product Information. Xeloda (capecitabine)." Roche Laboratories PROD (2001):
- "Product Information. Alkeran (melphalan)." Glaxo Wellcome (2022):
- "Product Information. Purinethol (mercaptopurine)." Glaxo Wellcome PROD (2001):
- "Product Information. Leukeran Tablets (chlorambucil)." Glaxo Welcome, Research Triangle Pk, NC.
- "Product Information. Doxil (doxorubicin liposomal)." Sequus Pharmaceuticals Inc PROD (2001):
- "Product Information. Cytosar-U (cytarabine)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Uracil Mustard (uracil mustard)." Roberts Pharmaceutical Corporation PROD (2001):
- "Product Information. Jevtana (cabazitaxel)." sanofi-aventis (2010):
- "Product Information. Halaven (eribulin)." Eisai Inc (2010):
- "Product Information. Pepaxto (melphalan flufenamide)." Oncopeptides Inc. (2021):
Mercaptopurine (applies to Purinethol) hepatic dysfunction
Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Mercaptopurine is hepatotoxic. Hepatic injury can occur at any dosage, however, increased frequency of injury occurs when doses exceed 2.5 mg/kg/day. Deaths due to hepatic necrosis have been reported. Patients should be instructed to immediately report any signs of hepatotoxicity such as jaundice, hepatic dysfunction such as, jaundice, dark urine, right upper quadrant pain, or anorexia. Therapy with mercaptopurine should be administered cautiously in patients with or predisposed to compromised hepatic function. Clinical monitoring of hepatic function and determination of the etiology of hepatic dysfunction is recommended.
References
- "Product Information. Purinethol (mercaptopurine)." Glaxo Wellcome PROD (2001):
Mercaptopurine (applies to Purinethol) myelosuppression
Major Potential Hazard, High plausibility. Applicable conditions: Bleeding, Bone Marrow Depression/Low Blood Counts, Fever
Mercaptopurine induces dose-related myelosuppression which can be delayed. Leukopenia, thrombocytopenia, and anemia have been reported during mercaptopurine therapy. Therapy should be administered cautiously in patients with myelosuppression and therapy should be withheld at the first indication of an abnormally large reduction of any bone marrow element. Patients should be instructed to immediately report any signs or symptoms suggesting bone marrow suppression such as fever, sore throat, local infection, or bleeding. Close monitoring of hematopoietic function is recommended.
References
- "Product Information. Purinethol (mercaptopurine)." Glaxo Wellcome PROD (2001):
Thioguanine (applies to Purinethol) TMPT enzyme deficiency
Major Potential Hazard, Moderate plausibility. Applicable conditions: Enzymopathy (Unspecified)
Thioguanine is closely related structurally and functionally to mercaptopurine. A rare deficiency in the enzyme thiopurine methyltransferase (TMPT) results in an increased sensitivity to the myelosuppressive effects of both drugs causing rapid bone marrow suppression following initial mercaptopurine or thioguanine administration. Therapy with thioguanine or mercaptopurine should be administered cautiously and at a reduced dose in patients with TMPT deficiency.
References
- "Product Information. Tabloid (thioguanine)." Prasco Laboratories PROD (2001):
Mercaptopurine (applies to Purinethol) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Mercaptopurine is excreted in the urine as unchanged drug and metabolites. Renal elimination may be reduced in patients with impaired renal function. Therapy with mercaptopurine should be initiated at a reduced dosage in patients with compromised renal function. Clinical monitoring of renal function is recommended.
References
- "Product Information. Purinethol (mercaptopurine)." Glaxo Wellcome PROD (2001):
Purinethol drug interactions
There are 280 drug interactions with Purinethol (mercaptopurine).
Purinethol alcohol/food interactions
There is 1 alcohol/food interaction with Purinethol (mercaptopurine).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.