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Mercaptopurine Pregnancy and Breastfeeding Warnings

Mercaptopurine is also known as: Purinethol, Purixan

Mercaptopurine Pregnancy Warnings

Mercaptopurine has been assigned to pregnancy category D by the FDA. Women receiving mercaptopurine in the first trimester have been reported to have an increased incidence of abortions. Out of 28 women who received mercaptopurine after the first trimester, three mothers died undelivered, one mother delivered a stillborn child, and one mother aborted. There are no controlled data in human pregnancy. Mercaptopurine should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Mercaptopurine Breastfeeding Warnings

There are no data on the excretion of mercaptopurine into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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