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Casgevy Disease Interactions

There are 4 disease interactions with Casgevy (exagamglogene autotemcel).

Moderate

Exagamglogene (applies to Casgevy) Bone marrow transplantation

Moderate Potential Hazard, Moderate plausibility.

Exagamglogene has not been studied in patients who received allogeneic or autologous hematopoietic stem cell transplants. Treatment with exagamglogene is not recommended in these patients.

References

  1. (2023) "Product Information. Casgevy (exagamglogene autotemcel)." Vertex Pharmaceuticals
Moderate

Exagamglogene (applies to Casgevy) HIV and Hepatitis infections

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: HIV Infection, Infectious Hepatitis

Exagamglogene has not been studied in patients with HIV-1, HIV-2, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections. Patients should be screened for these infectious agents before collection of cells for manufacturing. Exagamglogene should not be used in patients with active HIV-1, HIV-2, HBV, or HCV.

References

  1. (2023) "Product Information. Casgevy (exagamglogene autotemcel)." Vertex Pharmaceuticals
Moderate

Exagamglogene (applies to Casgevy) Liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Exagamglogene has not been studied in patients with hepatic impairment. Patients should be assessed for hepatic impairment to ensure that hematopoietic stem cell transplantation is appropriate.

References

  1. (2023) "Product Information. Casgevy (exagamglogene autotemcel)." Vertex Pharmaceuticals
Moderate

Exagamglogene (applies to Casgevy) Renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Exagamglogene has not been studied in patients with renal impairment (estimated glomerular filtration rate less than 60 mL/min/1.73 m2). Patients should be assessed for renal impairment prior to treatment to ensure that hematopoietic stem cell transplantation is appropriate.

References

  1. (2023) "Product Information. Casgevy (exagamglogene autotemcel)." Vertex Pharmaceuticals

Casgevy drug interactions

There are 102 drug interactions with Casgevy (exagamglogene autotemcel).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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