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Daratumumab/hyaluronidase Disease Interactions

There are 2 disease interactions with daratumumab / hyaluronidase.

Moderate

Daratumumab (applies to daratumumab/hyaluronidase) cytopenias

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Neutropenia, Thrombocytopenia

The use of daratumumab may increase neutropenia and thrombocytopenia induced by background therapy. It is recommended to monitor complete blood cell counts periodically during treatment according to manufacturer's prescribing information for background therapies. Dose delay may be required to allow recovery of neutrophils and platelets and supportive care should be considered.

References

  1. (2015) "Product Information. Darzalex (daratumumab)." Janssen Biotech, Inc.
Moderate

Daratumumab (applies to daratumumab/hyaluronidase) infusion reactions

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Chronic Obstructive Pulmonary Disease

The use of daratumumab can cause severe infusion reactions, including bronchospasm, hypoxia, dyspnea, hypertension, laryngeal edema and pulmonary edema. Caution should be taken in patients with a history of chronic obstructive pulmonary disease as they may require additional post-infusion medications to manage respiratory complications as appropriate.

References

  1. (2015) "Product Information. Darzalex (daratumumab)." Janssen Biotech, Inc.

Daratumumab/hyaluronidase drug interactions

There are 233 drug interactions with daratumumab / hyaluronidase.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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