Skip to main content

Dacomitinib Disease Interactions

There are 2 disease interactions with dacomitinib.

Moderate

Dacomitinib (applies to dacomitinib) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

The recommended dose of dacomitinib has not been established for patients with severe renal impairment (CrCl <30 mL/min). Caution is advised if used in these patients. No dose adjustment is recommended for patients with mild or moderate renal impairment.

References

  1. (2018) "Product Information. Vizimpro (dacomitinib)." Pfizer U.S. Pharmaceuticals Group
Moderate

Dacomitinib (applies to dacomitinib) severe hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The recommended dose of dacomitinib has not been established for patients with severe hepatic impairment (total bilirubin > 3 to 10 × ULN and any AST). Caution is advised if used in these patients. No dose adjustment is recommended in patients with mild or moderate hepatic impairment.

References

  1. (2018) "Product Information. Vizimpro (dacomitinib)." Pfizer U.S. Pharmaceuticals Group

Dacomitinib drug interactions

There are 92 drug interactions with dacomitinib.

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer