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Cysteamine Disease Interactions

There are 3 disease interactions with cysteamine.

Major

Cysteamine (applies to cysteamine) alcoholism

Major Potential Hazard, Moderate plausibility.

The use of alcohol may increase the rate of cysteamine release and/or adversely alter the pharmacokinetic properties, as well as the effectiveness and safety. It is recommended to avoid the consumption of alcoholic beverages during treatment with cysteamine.

References

  1. (2013) "Product Information. Procysbi (cysteamine)." Raptor Pharmaceutical Corporation
Moderate

Cysteamine (applies to cysteamine) GI disorders

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Hemorrhage, Inflammatory Bowel Disease

Gastrointestinal tract symptoms including nausea, vomiting, anorexia, abdominal pain, gastrointestinal ulceration and bleeding have been associated with cysteamine, sometimes severe. Caution is advised in patients with gastrointestinal disorders or history if gastrointestinal ulcers or bleeding. Physicians should follow patients for signs and symptoms of gastrointestinal ulceration and bleeding, and should inform patients and/or guardians of the importance of this follow-up.

References

  1. (2013) "Product Information. Procysbi (cysteamine)." Raptor Pharmaceutical Corporation
Moderate

Cysteamine (applies to cysteamine) liver disease

Moderate Potential Hazard, Moderate plausibility.

The use of cysteamine has been associated with development of hepatic coma in patients with overt hepatic damage. Therapy with cysteamine should be administered cautiously in patients with liver disease.

References

  1. (2001) "Product Information. Cystagon (cysteamine)." Mylan Pharmaceuticals Inc

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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