Brexanolone Disease Interactions
There are 2 disease interactions with brexanolone.
Brexanolone (applies to brexanolone) renal impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
The effect of end stage renal disease (ESRD, eGFR < 15 mL/minute/1.73 m2) on brexanolone pharmacokinetics is unknown, and its use should be avoided in these patients because of the potential accumulation of the solubilizing agent, betadex sulfobutyl ether sodium. No dosage adjustment is recommended in patients with mild (eGFR 60 to 89 mL/minute/1.73 m2), moderate (eGFR 30 to 59 mL/minute/1.73 m2) or severe (eGFR 15 to 29 mL/minute/1.73 m2) renal impairment.
References
- (2019) "Product Information. Zulresso (brexanolone)." Sage Therapeutics, Inc.
Brexanolone (applies to brexanolone) depression
Moderate Potential Hazard, Moderate plausibility.
Brexanolone is indicated for the treatment of postpartum depression. A placebo-controlled trial showed that patients with a previous diagnosis of major depressive disorder (MDD) had a higher incidence of suicidal thoughts and behaviors when treated with brexanolone. Consider changing the therapeutic regimen, including discontinuing brexanolone, in patients whose depression becomes worse or who experience emergent suicidal thoughts and behaviors.
References
- (2019) "Product Information. Zulresso (brexanolone)." Sage Therapeutics, Inc.
Brexanolone drug interactions
There are 272 drug interactions with brexanolone.
Brexanolone alcohol/food interactions
There is 1 alcohol/food interaction with brexanolone.
More about brexanolone
- brexanolone consumer information
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- Dosage information
- During pregnancy
- Drug class: miscellaneous antidepressants
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.