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Boceprevir Disease Interactions

There is 1 disease interaction with boceprevir.

Moderate

Boceprevir (applies to boceprevir) pancytopenia

Moderate Potential Hazard, Moderate plausibility.

Anemia, neutropenia and thrombocytopenia has been reported with the use of boceprevir. Boceprevir is always administered with peginterferon alfa and ribavirin which are also associated with pancytopenia. The addition of boceprevir has shown an additional decrease in hemoglobin and blood cell counts. Caution should be used in patients with preexisting anemia, neutropenia or thrombocytopenia. A complete blood count should be obtained pretreatment, and then during treatment at weeks 2, 4, 8, and 12. Patients should be monitored closely. Refer to the prescribing information for peginterferon alfa and ribavirin for additional information regarding dose reduction or discontinuation based on laboratory parameters. If ribavirin and peginterferon alfa need to be discontinued, boceprevir should be discontinued as well.

References

  1. "Product Information. Victrelis (boceprevir)." Schering-Plough Corporation (2011):

Boceprevir drug interactions

There are 452 drug interactions with boceprevir.

Boceprevir alcohol/food interactions

There is 1 alcohol/food interaction with boceprevir.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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