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Orladeyo Disease Interactions

There is 1 disease interaction with Orladeyo (berotralstat).

Moderate

Berotralstat (applies to Orladeyo) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Berotralstat has not been studied in patients with end-stage renal disease (CrCl < 15 mL/min or patients requiring hemodialysis), and its use is not recommended in these patients. No dosage adjustment is recommended for patients with mild, moderate or severe renal impairment.

References

  1. (2021) "Product Information. Orladeyo (berotralstat)." BioCryst Pharmaceuticals Inc

Orladeyo drug interactions

There are 450 drug interactions with Orladeyo (berotralstat).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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