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Belantamab mafodotin Disease Interactions

There are 3 disease interactions with belantamab mafodotin.

Major

Belantamab mafodotin (applies to belantamab mafodotin) visual disturbances

Major Potential Hazard, Moderate plausibility. Applicable conditions: Visual Defect/Disturbance

Belantamab has caused ocular toxicity resulting in changes in vision, including severe vision loss and corneal ulcer, and symptoms such as blurred vision and dry eyes. Caution and close monitoring is advised in patients with preexisting visual disturbances. Ophthalmic exams should be performed at baseline, prior to each dose, and promptly for new or worsening symptom. Due to the risk of ocular toxicity, this drug is only available through a restricted program under the Risk Evaluation and Mitigation Strategy (REMS).

References

  1. (2020) "Product Information. Blenrep (belantamab mafodotin)." GlaxoSmithKline
Moderate

Belantamab mafodotin (applies to belantamab mafodotin) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Belantamab has not been studied in patients with moderate or severe hepatic impairment. Caution is advised. No dosage modification is required in patients with mild hepatic impairment.

References

  1. (2020) "Product Information. Blenrep (belantamab mafodotin)." GlaxoSmithKline
Moderate

Belantamab mafodotin (applies to belantamab mafodotin) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Belantamab has not been studied in patients with severe renal impairment, or end-stage renal disease not on dialysis or in dialysis. Caution is advised. No dosage modification is required in patients with mild or moderate renal impairment.

References

  1. (2020) "Product Information. Blenrep (belantamab mafodotin)." GlaxoSmithKline

Belantamab mafodotin drug interactions

There are 164 drug interactions with belantamab mafodotin.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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