Tylenol Extra Strength (acetaminophen) Disease Interactions

There are 3 disease interactions with Tylenol Extra Strength (acetaminophen):

Although rarely reported, chronic alcohol abusers may be at increased risk of hepatotoxicity from excessive use of acetaminophen (APAP). Therapy with APAP should be administered cautiously in patients who consume three or more alcoholic drinks a day. These patients should be warned not to exceed the recommended dosage (maximum 4 g/day in adults and children 12 years of age or older).

Acetaminophen (APAP) is primarily metabolized in the liver to inactive forms. However, small quantities are converted by minor pathways to metabolites that can cause hepatotoxicity or methemoglobinemia. Patients with hepatic impairment may be at increased risk of APAP-associated toxicity due to increased minor metabolic pathway activity. Likewise, chronic or overuse of APAP can saturate the primary hepatic enzymes and lead to increased metabolism by minor pathways. Therapy with APAP should be administered cautiously in patients with hepatic insufficiency. Clinical monitoring of hepatic function is recommended.

Several oral acetaminophen and acetaminophen-combination products, particularly flavored chewable tablets, contain the artificial sweetener, aspartame (NutraSweet). Aspartame is converted to phenylalanine in the gastrointestinal tract following ingestion. Chewable and effervescent formulations of acetaminophen products may also contain phenylalanine. The aspartame/phenylalanine content should be considered when these products are used in patients who must restrict their intake of phenylalanine (i.e. phenylketonurics).

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Tylenol Extra Strength (acetaminophen) drug Interactions

There are 136 drug interactions with Tylenol Extra Strength (acetaminophen)

Tylenol Extra Strength (acetaminophen) food/lifestyle Interactions

There is 1 food/lifestyle interaction with Tylenol Extra Strength (acetaminophen)

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