Diclegis

Generic Name: doxylamine and pyridoxine (dox IL a meen and PIR i DOX een)
Brand Names: Diclegis

What is Diclegis?

Diclegis is a delayed-release tablet containing a combination of doxylamine and pyridoxine. Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body.

Pyridoxine is a form of vitamin B (B6).

Diclegis is used to treat nausea and vomiting during pregnancy, sometimes called morning sickness.

Diclegis may also be used for purposes not listed in this medication guide.

Important information

Do not use Diclegis if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

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Before taking this medicine

Do not use Diclegis if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use this medicine if you are allergic to doxylamine or pyridoxine, or to other antihistamines such as Benadryl or Dramamine.

To make sure this medicine is safe for you, tell your doctor if you have:

  • asthma or other breathing disorder;

  • glaucoma, increased pressure inside your eye;

  • blockage in your digestive tract (stomach or intestines);

  • a stomach ulcer; or

  • bladder obstruction or other urination problems.

FDA pregnancy category A. Diclegis is not expected to harm an unborn baby.

See also: Pregnancy and breastfeeding warnings (in more detail)

Doxylamine and pyridoxine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Do not give this medication to anyone under 18 years old without medical advice.

How should I take Diclegis?

Take Diclegis exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Do not crush, chew, or break a delayed-release tablet. Swallow it whole.

Diclegis is usually taken at bedtime on an empty stomach, at least 2 hours after a meal.

If your symptoms do not improve, you may need to take 1 tablet in the morning, 1 tablet in the afternoon, and 2 tablets at bedtime. Follow your doctor's instructions.

Call your doctor if your symptoms get worse while using Diclegis. Severe or ongoing vomiting can cause you to become dehydrated which can lead to serious medical problems.

Diclegis dosing information

Usual Adult Dose for Nausea/Vomiting:

During Pregnancy:

2 tablets orally at bedtime
Maximum dose: 4 tablets daily

Comments: Take daily and not on an as needed basis

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include dry mouth, extreme drowsiness or dizziness, confusion, restless feeling, dilated pupils, rapid heartbeats, seizure (convulsions), or unexplained muscle pain or weakness with fever and dark colored urine.

What should I avoid while taking Diclegis?

Diclegis may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you.

Avoid drinking alcohol. It can increase drowsiness caused by Diclegis.

Many medicines available over the counter can increase drowsiness caused by Diclegis. Ask a doctor or pharmacist before using any cough/cold, allergy, pain, or sleep medication. Severe drowsiness can cause falls or other accidents.

Do not take any medicine without your doctor's advice while you are pregnant.

Diclegis side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Diclegis: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common Diclegis side effects may include:

  • drowsiness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Diclegis?

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Diclegis with any medications you use to treat depression, mental illness, or seizures.

Other drugs may interact with doxylamine and pyridoxine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about Diclegis.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Diclegis only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 1.01. Revision Date: 2013-10-23, 9:28:08 AM.

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