Diclegis Side Effects

Generic Name: doxylamine / pyridoxine

Note: This page contains information about the side effects of doxylamine / pyridoxine. Some of the dosage forms included on this document may not apply to the brand name Diclegis.

Not all side effects for Diclegis may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to doxylamine / pyridoxine: oral tablet delayed release, oral tablet extended release

Along with its needed effects, doxylamine / pyridoxine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking doxylamine / pyridoxine:

Incidence not known
  • Chest discomfort
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult or labored breathing
  • difficult or painful urination
  • fast, irregular, pounding, or racing heartbeat or pulse
  • swelling of the eyelids, face, lips, hands, or feet

Some side effects of doxylamine / pyridoxine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Unusual drowsiness

For Healthcare Professionals

Applies to doxylamine / pyridoxine: oral delayed release tablet


Postmarketing reports: Palpitation, tachycardia


Postmarketing reports: Hyperhidrosis, pruritus, rash, maculo-papular rash


Postmarketing reports: Abdominal distension, abdominal pain, constipation, diarrhea


Postmarketing reports: Hypersensitivity

Nervous system

Very common (10% or more): Somnolence (14.3%)
Postmarketing reports: Vertigo, dizziness, headache, migraines, paresthesia, psychomotor hyperactivity


Postmarketing reports: Blurred vision, visual disturbances


Postmarketing reports: Chest discomfort, fatigue, irritability, malaise


Postmarketing reports: Anxiety, disorientation, insomnia, nightmares


Postmarketing reports: Dysuria, urinary retention


Postmarketing reports: Dyspnea

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