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Vincasar PFS

Generic Name: vincristine (Intravenous route)

vin-KRIS-teen

Intravenous route(Solution)

For intravenous use only; fatal if given intrathecally. Intravenous needle or catheter must be properly positioned before any vincristine is injected as leakage into the surrounding tissue may cause considerable irritation. If extravasation occurs, the injection should be discontinued immediately, and any remaining portion of the dose should then be introduced into another vein. Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis .

Commonly used brand name(s)

In the U.S.

  • Oncovin
  • Vincasar PFS

Available Dosage Forms:

  • Powder for Solution
  • Solution

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Mitotic Inhibitor

Uses For Vincasar PFS

Vincristine belongs to the group of medicines known as antineoplastic agents. It is used to treat some kinds of cancer as well as some noncancerous conditions.

Vincristine interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by vincristine, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, such as hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Slideshow: Flashback: FDA Drug Approvals 2013

Before you begin treatment with vincristine, you and your doctor should talk about the good this medicine will do as well as the risks of using it.

Vincristine is to be administered only by or under the immediate supervision of your doctor.

Before Using Vincasar PFS

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in children and has not been shown to cause different side effects or problems than it does in adults.

Geriatric

Nervous system effects may be more likely to occur in the elderly, who are usually more sensitive to the effects of vincristine.

Pregnancy

Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Boceprevir
  • Cobicistat
  • Rotavirus Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenovirus Vaccine Type 4, Live
  • Adenovirus Vaccine Type 7, Live
  • Amiodarone
  • Aprepitant
  • Asparaginase
  • Atazanavir
  • Azithromycin
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Bosutinib
  • Captopril
  • Carbamazepine
  • Carvedilol
  • Clarithromycin
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Dabrafenib
  • Dexamethasone
  • Diltiazem
  • Dronedarone
  • Erythromycin
  • Eslicarbazepine Acetate
  • Felodipine
  • Filgrastim
  • Fluconazole
  • Fosaprepitant
  • Fosphenytoin
  • Indinavir
  • Influenza Virus Vaccine, Live
  • Itraconazole
  • Ketoconazole
  • Lomitapide
  • Lopinavir
  • Measles Virus Vaccine, Live
  • Mitotane
  • Mumps Virus Vaccine, Live
  • Nefazodone
  • Nelfinavir
  • Nilotinib
  • Phenobarbital
  • Phenytoin
  • Piperaquine
  • Posaconazole
  • Primidone
  • Quercetin
  • Quinidine
  • Quinupristin
  • Ranolazine
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Rubella Virus Vaccine, Live
  • Saquinavir
  • Sargramostim
  • Simeprevir
  • Smallpox Vaccine
  • St John's Wort
  • Telaprevir
  • Telithromycin
  • Ticagrelor
  • Tocophersolan
  • Tolvaptan
  • Typhoid Vaccine
  • Valspodar
  • Varicella Virus Vaccine
  • Verapamil
  • Voriconazole
  • Warfarin
  • Yellow Fever Vaccine
  • Zidovudine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Nifedipine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Chickenpox (including recent exposure) or
  • Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body
  • Gout (history of) or
  • Kidney stones (history of)—Vincristine may increase levels of uric acid in the body, which can cause gout or kidney stones
  • Infection—Vincristine can reduce immunity to infection
  • Liver disease—Effects may be increased because of slower removal of vincristine from the body
  • Nerve or muscle disease—May be worsened

Proper Use of vincristine

This section provides information on the proper use of a number of products that contain vincristine. It may not be specific to Vincasar PFS. Please read with care.

Vincristine is often given together with certain other medicines. If you are using a combination of medicines, it is important that you receive each one at the proper time. If you are taking some of these medicines by mouth, ask your health care professional to help you plan a way to take them at the right times.

While you are using this medicine, it may be necessary to drink extra fluids so that you will pass more urine. This will help prevent kidney problems and keep your kidneys working well. Ask your doctor if this is necessary for you.

This medicine sometimes causes nausea and vomiting. However, it is very important that you continue to receive the medicine, even if you begin to feel ill. Ask your health care professional for ways to lessen these effects.

Vincristine frequently causes constipation and stomach cramps. Your doctor may want you to take a laxative. However, do not decide to take these medicines on your own without first checking with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Precautions While Using Vincasar PFS

It is very important that your doctor check your progress at regular visits to make sure that vincristine is working properly and to check for unwanted effects.

While you are being treated with vincristine, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Vincristine may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. Other people living in your household should not take or should not have recently taken oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid other persons who have taken oral polio vaccine. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

If vincristine accidentally seeps out of the vein into which it is injected, it may damage some tissues and cause scarring. Tell the doctor or nurse right away if you notice redness, pain, or swelling at the place of injection.

Vincasar PFS Side Effects

Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, nervous system problems, loss of hair, and other side effects. These and others are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Pain or redness at place of injection
Rare
  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Check with your doctor as soon as possible if any of the following side effects occur:

More common
  • Blurred or double vision
  • constipation
  • difficulty in walking
  • drooping eyelids
  • headache
  • jaw pain
  • joint pain
  • lower back or side pain
  • numbness or tingling in fingers and toes
  • pain in fingers and toes
  • pain in testicles
  • stomach cramps
  • swelling of feet or lower legs
  • weakness
Less common
  • Agitation
  • bed-wetting
  • confusion
  • convulsions (seizures)
  • decrease or increase in urination
  • dizziness or lightheadedness when getting up from a lying or sitting position
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • lack of sweating
  • loss of appetite
  • mental depression
  • painful or difficult urination
  • trouble in sleeping
  • unconsciousness
Rare
  • Sores in mouth and on lips

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Bloating
  • diarrhea
  • loss of weight
  • nausea and vomiting
  • skin rash

Other side effects may occur that usually do not need medical attention. This medicine often causes a temporary loss of hair. After treatment with vincristine has ended, or sometimes even during treatment, normal hair growth should return.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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