Vincristine Pregnancy and Breast Feeding Warnings

Vincristine is also known as: Oncovin, Vincasar PFS

Overview

Vincristine has been shown to cause harm to the fetus. Avoid becoming pregnant while taking Vincristine . If you think you may be pregnant, discuss with your doctor the benefits and risks of using Vincristine during pregnancy. It is unknown if Vincristine is excreted in breast milk. Do not breast-feed while taking Vincristine .

Vincristine Pregnancy Warnings

Vincristine has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of teratogenicity. When administered as a part of combination antineoplastic therapy, vincristine may produce gonadal dysfunction in men and women. There are no controlled data in human pregnancy. Vincristine should only be given during pregnancy when there are no alternatives and benefit outweighs risk. If this drug is used during pregnancy, or if the patient becomes pregnant while receiving this drug, she should be apprised of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant while receiving this medication.

Clinical reports of both male and female patients who received vincristine as a part of multiple agent chemotherapy indicate that azoospermia and amenorrhea can occur in postpubertal patients. Recovery occurred in some of the patients many months after the chemotherapy had been completed. In studies of several animal species, the drug has induced teratogenesis or embryonic fatality at dosages which were nontoxic to the pregnant animals.

Vincristine Lactation Warnings

There are no data on the excretion of vincristine into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions to vincristine in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.

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