Skip to main content

S-adenosylmethionine for Osteoarthritis User Reviews

Brand names: SAMe, Natrol SAMe, Adomet

S-adenosylmethionine has an average rating of 6.7 out of 10 from a total of 6 reviews for the off-label treatment of Osteoarthritis. 67% of reviewers reported a positive experience, while 33% reported a negative experience.

S-adenosylmethionine rating summary

6.7/10 average rating

6 ratings from 6 user reviews.

Compare all 184 medications used in the treatment of Osteoarthritis.

10
50%
9
0%
8
17%
7
0%
6
0%
5
0%
4
0%
3
0%
2
0%
1
33%
  • Chris
  • Taken for 1 to 6 months
  • February 15, 2020

"I have never been blown away by a natural supplement like Sam-e. A year after major back surgery and a hip replacement, I was in more pain than before the surgeries.. chronic.. debilitating pain. I researched sam-e and decided to try it. Started with two 400 mg tablets a day and after a week, I felt like my pain was decreasing. I increased to three tablets a day and it's now been a month.. and I'm a new man. Sam-e is remarkable. It not only works for joint pain, but also overall muscle and body pain.. my mobility is returning to normal... a fabulous supplement :)"

10 / 10
Was this helpful?YesNo
68 Report
  • Ukie
  • December 21, 2014

SAMe (s-adenosylmethionine) "I like SAMe it keeps my mood even and I have arthritis and anxiety. Have had pain remission ever since starting SAMe over 8 months ago. I take it with Super B Complex which is recommended to keep homocysteine levels even . It works great as a mood elevator. Love it"

10 / 10
Was this helpful?YesNo
109 Report
  • jasbeau
  • Taken for 1 to 6 months
  • June 1, 2021

"Used 1200mg a day for a month. Had wild dreams starting week three. No noticeable arthritis relief. Reduced to 400mg after week four. Still very bad dreams and no arthritis help. Stopped after six weeks."

1 / 10
Was this helpful?YesNo
18 Report
  • roxdr...
  • March 9, 2010

"During my treatment of depression and RA--it seemed all the medicines stopped working at the same time. I was taking Cymbalta. I tapered off of it and tried Pristiq which worked horribly. I stopped taking them all and researched natural remedies for depression--came across lithium orotate and SAMe. I have been taking both for a couple of months now--seems to keep me level and out of the depressed state that I was in, so for now it seems to be working."

8 / 10
Was this helpful?YesNo
42 Report
  • Carol
  • Taken for 1 to 6 months
  • October 1, 2023

"I am a 75-year-old active woman. My doctor recommended I take 400 mg of SAMe daily for hip and leg pain. I have been taking it for 3 months, and it has worked wonders for me. I have very little pain now when I take my daily walks or garden, and I seem to have more energy. I don't have side effects from it, which I had when I took OTC pain medications, such as bad dreams and stomach upset."

10 / 10
Was this helpful?YesNo
3 Report
  • Heywood
  • Taken for 1 to 6 months
  • April 30, 2015

SAMe (s-adenosylmethionine) "It works but side effects with digestion so bad Had to stop it."

1 / 10
Was this helpful?YesNo
53 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

Learn more about Osteoarthritis

Care guides

Symptoms and treatments

Medicine.com guides (external)

More about s-adenosylmethionine

Patient resources

Professional resources

Other brands

SAMe

Related treatment guides