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Rifampin User Reviews & Ratings

Brand names: Rifadin, Rifadin IV, Rimactane

Rifampin has an average rating of 6.2 out of 10 from a total of 21 reviews on Drugs.com. 42% of reviewers reported a positive experience, while 21% reported a negative experience.

Condition Avg. Rating Reviews Compare
Mycobacterium avium-intracellulare, Treatment  Off-label
5.3
3 reviews for Mycobacterium avium-intracellulare, Treatment 13 medications
Tuberculosis, Latent  
5.3
14 reviews for Tuberculosis, Latent 5 medications
Nasal Carriage of Staphylococcus aureus  
9.0
1 reviews for Nasal Carriage of Staphylococcus aureus 7 medications
Bartonellosis  
10.0
1 reviews for Bartonellosis 36 medications
Tuberculosis, Active  
10.0
1 reviews for Tuberculosis, Active 30 medications
Tuberculosis, Prophylaxis  
10.0
1 reviews for Tuberculosis, Prophylaxis 6 medications
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Reviews for Rifampin

  • Latent
  • Taken for less than 1 month
  • September 2, 2019

For Tuberculosis, Latent "I have been started on Rifampin 600mg every day for 4 months for Latent TB. First week was okay, but starting the second week, I’ve had severe headache and sore throat. I had to be rushed to the ER due to the severe pain in my head and neck with difficulty in swallowing. CT scan showed that I have enlarged lymph nodes on both sides of my neck. My blood sugar also is elevated. The doctor prescribed me Motrin as needed for my headache, and it has been working. It is true that Rifampin treatment is a tough one. I’m happy for those who experience only minor side effects. Please do pray for me. Thank you."

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26 Report
  • CAcat
  • Taken for 1 to 6 months
  • January 9, 2020

For Tuberculosis, Latent "I was on this medication for 4 months for latent tuberculosis not terrible at all and way better than the other 9 month treatment. Only side effects I experienced were the color change of fluids some lightheadedness and minor arthritis pain."

9 / 10
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18 Report
  • turno...
  • April 25, 2016

For Tuberculosis, Latent "I've been on Rifampin for one month and I've had all sorts of side effects. Some days I'm fine, other days not so much. At night I break out in sweats, I got thrush so I had to take medicine for that. I go to doctor in a couple of days and I need to find out if I can stop it. I don't want to go through this for 3 more months."

4 / 10
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25 Report

Frequently asked questions

  • LWD
  • Taken for 1 to 6 months
  • January 17, 2015

For Tuberculosis, Latent "I just finished a 4 month regimen of Rifampin. It was prescribed when I was tested for TB in preparation for starting on a biologic for Rheumatoid Arthritis. I have no idea how/when I was exposed to TB but I couldn't start the biologic until the latent TB was addressed. I will never know if it was "effective" since I will always test positive for TB antigens but I'm glad I took it-didn't have much of a choice! It was not an easy medication to take but I got through the course of treatment better than I anticipated. I did have slight nausea at the beginning and intermittent watery diarrhea throughout. I don't know if the other side effects (fatigue, primarily) I experienced were side effects of Rifampin or symptoms of rheumatoid arthritis."

8 / 10
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  • Hopeful
  • Taken for 1 to 2 years
  • June 24, 2022

For Mycobacterium avium-intracellulare, Treatment "I took Rifampin plus azithromycin and ethambutol for 17 months Rifampin in the morning then lunch later Then the other two drugs at around 3 pm, Dinner at 6 I tolerated these drugs well, had the itching burning wave of night sweats but kept going. Then a week ago after taking the Rifampin I head a serious headache plus the wave of sweats that would not ease up. I felt dizzy, nauseous with pain in my back and stomach. This lasted all day into the night and I kept drinking water to flush it out. By 4 am I felt some relief and after communicating with the doctor I stopped taking all the meds My potassium level is elevated from last blood work Now I’m praying the MAC does not come back I wish all of us well"

7 / 10
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Are you taking this medicine?

  • The...
  • Taken for 1 to 6 months
  • December 2, 2021

For Tuberculosis, Latent "I took this for a few months about 3 years ago now for suspected latent TB I contracted after a holiday in Thailand. I was quite apprehensive, but I had no serious side effects. Your urine is a bit of an alarm colour when you first see it! Had a minor freak out the first time. Pills are big, think I had some pins and needles in my feet, I can't really remember anything else of note, maybe some upset stomach. The only major difficulty I recall was not being able to drink alcohol, eat cured meats, tomatoes or cheese which was hard for me! I did forget a few times and realise while eating a cheese sandwich, it's then when you notice who strong it is, especially with cheese, sour cream etc - it made me feel faint, bit like a small panic attack. Very weird! As I recall it suddenly raise your blood pressure if you eat certain things, so do pay attention to the diet advice! All in all miles better than I expected, and about a 1000 times better than having TB. Best wishes."

9 / 10
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  • Anonymous
  • September 17, 2011

For Tuberculosis, Latent "This is a very intense antibiotic with persistent side effects. I have been on this medication for one month and continue to experience nausea and vomiting. I have been fortunate to not experience reddening of my saliva or tears, but other body fluids have changed. My hepatic enzymes have more than doubled baseline values and continue to climb. It does its job well, but it is a tough 4 months to get through."

5 / 10
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23 Report
  • GMCO
  • February 7, 2013

For Mycobacterium avium-intracellulare, Treatment "CURRENTLY on rifampin therapy along with ethambutol, zithromax, IV amikacin and prilosec for the MAC. experiencing numerous side effects to include diarrhea, nausea, intermittent episodes of severe vomiting, extreme fatigue, headaches (almost all the time), dizziness, double vision, generalized body aches, and severe cramps in my extremities. It is hard to tell which drug is the culprit. I have experienced two incidences of elevated liver enzymes, which have returned back to within normal limits so far. At this point in my therapy, there has been no documented improvement, but I am told to expect it to take up to two years of therapy for a cure. I will update my experience as time progresses."

3 / 10
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  • Anonymous
  • January 26, 2012

For Tuberculosis, Latent "Although it makes my urine darker yellow/orangish color, I rarely experience significant side effects. Occasionally it will upset my stomach, but once you eat that goes away. Hardest part is sticking to the schedule, but I'd rather worry about that for 4 months than 9 or more."

9 / 10
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  • Anonymous
  • December 9, 2011

For Bartonellosis "Wonderful antibiotic for Bartonellosis! Few side effects compared to some other antibiotics. High bilirubin levels is usually transient and just needs to be monitored. Has a very short half-life compared to Mycobutin but far less chance of getting a serious side effect. Much easier and less serious side effects than Bactrim."

10 / 10
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  • Mon
  • Taken for less than 1 month
  • March 2, 2020

For Tuberculosis, Latent "I was advised to take the rifampin treatment 3 weeks ago for latent TB and I am still taking it. My experience was terrible. I have fever everyday, nerve pain, I vomit, head ache and I also lose my appetite. Hope I will feel better, please pray for me."

5 / 10
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8 Report
  • GONEAL
  • Taken for 2 to 5 years
  • October 5, 2017

For Mycobacterium avium-intracellulare, Treatment "This is my update from previous comment ; I've been on this drug, 3 150 mg caps daily, since 10/2012 with a 6 month break after 2 yrs, at which time I regressed and had to be restarted on it; there are side effects I listed in prev. Review; my diarrhea is better; Fast heart rate; currently experiencing high feelings of anxiety, intermittent fever and chills; periodic severe L side pain in pancreas area; increased lethargy, weakness, painful joints esp. hips, knees, finger joints; wt of 85lbs; are newer & becoming a bit problematic, but I was advised when taken off my drugs for 6 months, if I require restarting therapy, I would remain on them for life. I'm at the end of my 5th yr now! I tend to require hospitalization each November."

6 / 10
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  • ayada
  • Taken for 1 to 6 months
  • April 30, 2020

For Tuberculosis, Latent "I have been on Rifampin for three months now for TB and I have one month left. The side effects of the medication are not severe, but they are annoying. At first, I noticed a decreased appetite, but that lasted only a month. I do, however, continue to have upper stomach pain and a feeling of extreme fullness after almost every meal (I take an OTC antacid and gas relief pill and that helps relieve some of the pain). I have developed a pretty bad acne rash on my forehead that was never there before I started Rifampin. I have also noticed frequent lightheadedness after standing up, which never happened before this medication. Lastly, I have experienced a weight loss of about 15 lbs since starting Rifampin. Overall, the medication is bearable, but it has been annoying and I will be happy when I no longer have to take it."

6 / 10
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  • Jill
  • Taken for 1 to 6 months
  • November 17, 2021

For Tuberculosis, Latent "My first day of R, diagnosed with latent TB. I took mine on empty stomach 2 hours later, I felt nausea and lightheaded. I ate and I took nap on my lunch time, then woke up groggy, and now I have a headache as I type this. Advil ok ? How can you functions with all the side effects?"

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  • Never...
  • Taken for less than 1 month
  • September 21, 2020

For Tuberculosis, Latent "Diagnosed with latent TB. So I took the 4 month treatment option 600 mg dosage thinking that would be the easy route. After a week , I had constant diarrhea and developed hives skin rash. Also developed joint pain around ankles and behind my knees. I told the doctor and immediately stopped taking Rifampin. It's been 4 weeks since that time, the hives are still there but luckily no more diarrhea and joint pain have lessened."

1 / 10
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  • Mini...
  • Taken for 1 to 6 months
  • April 17, 2020

For Tuberculosis, Latent "I was prescribed Rifampin in January of 2020 for latent TB. I have about 3 more weeks. When I first started taking it I only had headaches. The headaches subsided. As the months go by it gets worse. I now have no appetite, consistent diarrhea, extreme fatigue and nausea. I had to take this medication to be able to continue taking my RA medication. I will be so glad when this is over. It seems as if there is nothing that can be done."

1 / 10
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  • Bad...
  • Taken for less than 1 month
  • July 18, 2021

For Tuberculosis, Latent "This was a follow up to my previous review. In case anyone experiences this in the future turns out it was oral thrush developed either because of rifampin or my use of eye steroid drops. Rifampin after a few days did however elevate my thyroid levels. I do not plan on taking this medication in the near future only if the need is absolutely required."

2 / 10
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  • Tjak
  • November 11, 2016

For Nasal Carriage of Staphylococcus aureus "I am finishing up a six-week cycle of Rifampin in 6 days and all I have to say is about 2 weeks into the cycle I started to develop a severe leg pain in my achilles tendon area that has progressively gotten worse so bad I have had thoughts of calling 911 in the middle of the night due to the severe 10/10 pain has anyone else experienced pain in their foot leg or even arms and hands while taking Rifampin?"

9 / 10
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  • Tb ac...
  • Taken for 1 to 6 months
  • March 26, 2019

For Tuberculosis, Active "I have been on rifampin for 3 months for my tuberculosis and I have not experienced any negative side effects. I’ve felt really great with more energy."

10 / 10
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10 Report
  • Mon
  • Taken for 1 to 6 months
  • June 25, 2020

For Tuberculosis, Latent "Prescribed rifampin for latent TB infection. The first month the only side effect was headaches. Followed by insomnia, fatigue and the odd severe stomach cramp. Not a particularly nice drug!"

4 / 10
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  • this...
  • April 15, 2010

Rifadin (rifampin) for Tuberculosis, Prophylaxis "This is very helpful to me. Thanks."

10 / 10
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8 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.