Rifampin use while Breastfeeding
Drugs containing Rifampin: Rifadin, Rifater, Rimactane, IsonaRif, Rifadin IV, Rifamate
Rifampin Levels and Effects while Breastfeeding
Summary of Use during Lactation
Limited information indicates that there are low levels of rifampin in breastmilk that would not be expected to cause any adverse effects in breastfed infants. The amount of rifampin in milk is insufficient to treat tuberculosis in the breastfed infant. The Centers for Disease Control and Prevention and other professional organizations state that breastfeeding should not be discouraged in women taking rifampin.
Maternal Levels. One old study reported that after a single oral dose of rifampin of 150 mg, milk levels 4 hours after the dose ranged from 0 to 1.8 mg/L. After a single oral dose of 450 mg, milk levels 12 hours after the dose ranged from 3.4 to 4.9 mg/L. Details of the study and patients were not stated.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
One woman taking rifampin 450 mg, isoniazid 300 mg and ethambutol 1200 mg daily during pregnancy and rifampin 450 mg and isoniazid 300 mg for the first 7 months of lactation (extent not stated). The infant was born with mildly elevated serum liver enzymes which persisted for to 1 (alanine transferase) to 2 years (aspartate transaminase), but had no other adverse reactions.
Rifampin was used as part of multi-drug regimens to treat 2 pregnant women with multidrug-resistant tuberculosis throughout pregnancy and postpartum. Their two infants were breastfed (extent and duration not stated). At age 3.9 and 5.1 years, the children were developing normally except for hyperactivity in one.
Two mothers in Turkey were diagnosed with tuberculosis at the 30th and 34th weeks of pregnancy. They immediately started isoniazid 300 mg, rifampin 600 mg, pyridoxine 50 mg daily for 6 months, plus pyrazinamide 25 mg/kg and ethambutol 25 mg/kg daily for 2 months. Both mothers breastfed their infants (extent not stated). Their infants were given isoniazid 5 mg/kg daily for 3 months prophylactically. Tuberculin skin tests were negative after 3 months and neither infant had tuberculosis at 1 year of age. No adverse effects of the drugs were mentioned.
A woman with leprosy took clofazimine, dapsone and rifampin during pregnancy and breastfeeding. Her infant developed skin discoloration attributed to clofazimine which reversed 3 months after cessation of breastfeeding. Her previous child had a similar discoloration from breastfeeding with maternal clofazimine. Both infants were reportedly healthy.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
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6. Drobac PC, del Castillo H, Sweetland A et al. Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents. Clin Infect Dis. 2005;40:1689-92. PMID: 15889370
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8. Ozturk Z. Hansen's disease during pregnancy and lactation: Two babies born to a mother using antileprosy drugs. Naunyn-Schmiedeberg's Arch Pharmacol. 2016;389:S94-S95. Abstract. DOI: doi:10.1007/s00210-016-1213-y
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Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.