Rifampin use while Breastfeeding
Drugs containing Rifampin: Rifadin, Rimactane, Rifater, Rifamate, Rifadin IV, IsonaRif
Rifampin Levels and Effects while Breastfeeding
Summary of Use during Lactation
Limited information indicates that there are low levels of rifampin in breastmilk that would not be expected to cause any adverse effects in breastfed infants. The amount of rifampin in milk is insufficient to treat tuberculosis in the breastfed infant. The Centers for Disease Control and Prevention and other professional organizations state that breastfeeding should not be discouraged in women taking rifampin.
Maternal Levels. One old study reported that after a single oral dose of rifampin of 150 mg, milk levels 4 hours after the dose ranged from 0 to 1.8 mg/L. After a single oral dose of 450 mg, milk levels 12 hours after the dose ranged from 3.4 to 4.9 mg/L. Details of the study and patients were not stated.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
One woman taking rifampin 450 mg, isoniazid 300 mg and ethambutol 1200 mg daily during pregnancy and rifampin 450 mg and isoniazid 300 mg for the first 7 months of lactation (extent not stated). The infant was born with mildly elevated serum liver enzymes which persisted for to 1 (alanine transferase) to 2 years (aspartate transaminase), but had no other adverse reactions.
Rifampin was used as part of multi-drug regimens to treat 2 pregnant women with multidrug-resistant tuberculosis throughout pregnancy and postpartum. Their two infants were breastfed (extent and duration not stated). At age 3.9 and 5.1 years, the children were developing normally except for hyperactivity in one.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
1. Blumberg HM, Burman WJ, Chaisson RE et al. American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Respir Crit Care Med. 2003;167:603-62. PMID: 12588714
2. Anon. Treatment of tuberculosis. MMWR Recomm Rep. 2003;52:1-77. PMID: 12836625
3. Bartlett JG. Guidelines section. Infect Dis Clin Pract. 2002;11:467-71.
4. Lenzi E, Santauri S. [Preliminary observations on the use of a synthetic rifamycin derivative]. Atti Accad Lancisiana Roma. 1969;13 (Suppl 1):87-94.
5. Peters C, Nienhaus A. [Case report--tuberculosis in a health care worker during pregnancy]. Pneumologie. 2008;62:695-8. PMID: 18855309
6. Drobac PC, del Castillo H, Sweetland A et al. Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents. Clin Infect Dis. 2005;40:1689-92. PMID: 15889370
CAS Registry Number
- Antitubercular Agents
- Leprostatic Agents
LactMed Record Number
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- Rifampin use during Pregnancy
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- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy