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Seroquel XR User Reviews & Ratings (Page 2)

Seroquel XR has an average rating of 7.1 out of 10 from a total of 204 reviews on Drugs.com. 61% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Seroquel XR

  • Global...
  • January 25, 2017

For Depression "I have depression with anxious disitress.My extremely racing thoughts would typically whip me up into a panicky state, sometimes with outbursts of irrational anger. Seroquel XR works fantastically to ease that racing mind, to a more 'normal'and useful pace. Side effects are virtually absent: the XR doesn't floor me like immediate release Seroquel did. I can function and think well. Seroquel XR is a good medicine. It also helps with my depression."

10 / 10
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  • This...
  • Taken for less than 1 month
  • August 15, 2016

For Depression "I have only been on Seroquel XR for about a week at 50mg. My doctor prescribed it as an adjunct to Remeron to treat anxiety, depression, paranoia, and insomnia. I also take gabapentin, atenolol, and Xanax. When the Seroquel XR works, it WORKS. I can feel it sedating me two hours after I take it. I've been sleeping eight and nine hours a night, which has not happened in a very, very long time. It's effective at neutralizing both anxiety and depression. BUT... it doesn't last 24 hours for me; it only lasts about 15. Once it wears off my anxiety and depression return with a vengeance. Makes for a very rough 8 or 9 hours until I can take it again."

6 / 10
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  • garyb...
  • Taken for 1 to 6 months
  • May 10, 2016

For Depression "I've been on just about every antidepressant on the market and my doctor and I decided to try adjunct therapy with Seroquel to "boost" the effect of the Brintellix I take. I was really pleased to find it has a significant effect on my anxiety, which has always been a major component of my depression. While it didn't get rid of my depression, I feel better overall than I have in ages. Downsides? It's expensive if you don't have good insurance. I get a 90-day supply for $80. It also will knock you the heck out. I have to take mine before 6 p.m. or I will have great difficulty in waking up (even with an alarm). It has a heavy sedating effect."

8 / 10
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Frequently asked questions

  • Midni...
  • Taken for less than 1 month
  • April 23, 2013

For Depression "I have been on a few antidepressants for 11 years with only fair results. My Doctor started me on some Seroquel XR 200mg at bedtime over the last few weeks. This medication not only has helped me with the terrible side effects when you come off many of the typical SSRI but I am sleeping and my depression has improved from a 2 out of 10 to 7 out of ten. Sometimes, SSRI medication side effects are stated as minor but they can be very severe at times. More Doctors should know about Seroquel XR and the great results when stopping antidepressants."

7 / 10
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  • Arri
  • Taken for 1 to 6 months
  • November 11, 2015

For Depression "My experience on Seroquel nearly cost me my job as it turned me into a ZOMBIE!. Since going off the drug I am fully functional. My head is clear and I have energy to do things. I cannot believe my Dr prescribed me an antipsychotic drug such as seroquel. Colleagues observing me thought I had undergone a major personality disorder. I have been off it for a month now and not missing it one bit."

1 / 10
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Are you taking this medicine?

  • Anonymous
  • June 29, 2010

For Bipolar Disorder "I feel like this medication has saved my life. At the beginning of 2010, I had a mental breakdown. I was suffering from crying spells for no apparent reason and just did not want to live. I felt like I was watching someone go through the motions of my life and my true self was suffering and hurting. I made an emercency appointment with my psychiatrist. He started me at 50mg on day one, 100mg on day two, 150mg day three, 200mg day four and 300mg as maintenance. I used to have passive suicidal thoughts all the time and can now say that I don't. I've suffered from this condition for 12 years (Depersonalization Disorder). I've not known what it is like to not have depression until now. I feel like I owe my life to Seroquel XR."

9 / 10
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  • Brian...
  • Taken for less than 1 month
  • July 24, 2014

For Bipolar Disorder "I've only been on Seroquel for 2/3 weeks but I have had a largely positive experience. I have had a diagnosis of depression for about ten years and was using Cipralex (Lexapro). I came off Cipralex twice, and both times I became very depressed. Even on Cipralex my mood was constantly changing so I went to see a psychiatrist who thinks I may have Cyclothymia or bipolar 2 so started me on 50mg of Seroquel. Initially I was very groggy but have gotten over that. I've also gained a stone in weight. But my mood has really stabilised for the first time. I feel happy, confident and passionate. I no longer have a million thoughts in my head so can focus better. Hopefully this continues."

8 / 10
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  • Nix
  • January 18, 2012

For Depression "I've had depression for 12 years, and have been on Paxil about 10. The Paxil worked for a few years, but the anxiety and depression slowly worked its way back into my life. So along with the Paxil they added other drugs (Effexor, Wellbutrin) but they made me even more anxious. I was finally put on regular Seroquel and found it worked for a little while, but I was so tired all the time I couldn't function the next day. I was literally fired from 3 jobs from being stuck in bed and refusing to get up. I was switched to Seroquel XR 100mg last year combined with the 90mgs of Paxil I'm still on, and I've found a drastic improvement in my mood, anger and anxiety. My only complaint would be how sleepy it makes me in the mornings. A large coffee or a caffeinated beverage does the trick though and its worth the sleepiness to have some peace of mind."

8 / 10
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  • BanSe...
  • January 18, 2012

For Generalized Anxiety Disorder "SEVERE WEIGHT GAIN and METABOLIC SYNDROME! I had always suffered from anxiety from childhood to adulthood. My doctor prescribed a low dosage of 150 MG in December 2010, At the time I was prescribed Seroquel XR 150 MG, I weighed 96 lbs, petite frame, size 0 or 2. On January 11, 2012, I weighed in at 136 lbs. The 40 lbs of weight gain within one year went to my abdomen and I am covered in cellulite on my abs, hips, back, buttocks and thighs. I monitored my diet and intake the entire time, but the weight gain was out of control."

1 / 10
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  • Anonymous
  • Taken for less than 1 month
  • May 28, 2012

For Post Traumatic Stress Disorder "Within three days basically all my anxiety is gone, and I feel fantastic! FINALLY a doctor and psychologist worked together to treat what they said "unique" problem. I had anxiety all the time but wasn't depressed. So I'm one happy lady, and I'm sure my kids are loving there old mum back."

10 / 10
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  • Anonymous
  • September 30, 2008

For Depression "My 16 year old daughter has been in and out of the hospital for a year and 8 months with alot of ups and downs. She was given Seroquel xr and she is like a new person. She has gained weight from it and wanted to be taken off of it, but as the doctor started taking her off of it she did not like what was happening to her and said I would rather gain weight and be stable then skinny and angry and sad all the time."

10 / 10
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  • Anonymous
  • August 29, 2009

For Bipolar Disorder "I have heard all kinds of bad things about Seroquel but to me this medicine has saved my life. I was diagnosed with cyclothymia with racing thoughts and extreme hypo-manic phases followed by intense depression. Not to mention I would get so paranoid sometimes that I couldn't leave the house. I had tried everything including lithium but then I went to a new doctor. She said I could try Seroquel XR but I probably wouldn't like feeling sedated. I said sedated? fine! The funny thing is that I have had more energy but it is calm positive energy. I made a huge turn around and life is back on track. I thought I had ADHD as well but now I have great concentration, no anxiety, and can sit still for hours. I highly recommend if your symptoms sound like mine."

10 / 10
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  • Anonymous
  • November 5, 2020

For Bipolar Disorder "Listen to me when I say never & I mean never experiment with this drug Seroquel or Seroquel XR. It will only make your anxiety worse & if you have OCD your in for a nightmare. Worst drug ever & it will not help with your symptoms what so ever & will only help you sleep at night. Do not & I repeat do not get on this medication. On top of that you will have some of the craziest thoughts you could ever imagine."

1 / 10
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  • laven...
  • January 25, 2020

For Major Depressive Disorder "My mother rushed me to the hospital because I refused to get out of bed/wouldn’t stop talking about suicide. I was so tired from feeling LOW everyday, I thought there was no way I would ever regain will to live. Dr. rx’d me Seroquel 25mg once at bedtime so at least I wasn’t thinking about ending my life anymore. Suddenly I felt really heavy-drunk and could barely walk. The first day I slept for 20hr and when I woke up I was too tired to keep up my previous behaviour. After a couple days I whittled 20hr down to 8 and was sleeping normally. 6 months later I am at 100mg and 6 month away from that I am now on XR 200mg. Never have I felt better about my life. This is a tranquilizer. If you expect to drive cars/operate machines, you are seriously mistaken. It should not be taken in the morning due to its sedating effects. If you are someone who doesn’t need to “dull your brain”, I highly suggest you ask your doctor for another medication. There’s a reason it’s dubbed the shut-up-drug."

10 / 10
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  • Anonymous
  • December 12, 2010

For Bipolar Disorder "All I can say it that it is a miracle medicine. I finally have my life back. There are side effects but it is worth it. I am in college and doing well. My doctors said that would never happen for me. They said that I would be in and out of the psych ward. I have not need to be in hospital in over five years. I can finally hold a job. Like I said I have my life back, something I was told would never happen. Seroquel XR is that reason for that. Regular Seroquel is great too it just made me sleep for 18 hours a day. Seroquel XR makes me sleepy but I no longer over sleep. Again I say I got my life back."

10 / 10
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  • Curly...
  • Taken for 10 years or more
  • May 20, 2021

For Bipolar Disorder "I have been taking 800 mg Seroquel XR since 2012. I use to hold down two jobs . I always have worked since high school. I have no children , but was very close to my big family and involved in all events. Back in 2012 I had a hard time getting to sleep . Doctor put me on seroquel, said I was bipolar. I have never got mad at anyone and get along with everyone. I’m not an angry person. After taking this drug for awhile , it changed my life and ruined my relationship with family and friends. I became a zombie, I never answered my door and all I did was sleep. Missed out on many family events. Now my family are in my life and ask me what is wrong with me, I can’t stop moving my head from left to right., my doctor hasn’t done any blood work on me for several years. But he still has me taking these pills. I can’t function any more. The list goes on. I love life and always lived it. Until this drug came into my life"

1 / 10
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  • Indian...
  • Taken for 1 to 2 years
  • September 25, 2013

For Depression "I have been on 400mg of Seroquel XR along with my antidepressant for more than 1 year. Initially the medicine worked great for my Stress, Delusions and helped me sleep well in the night. Lately the anxiety has returned and I have severe anxiety during the day time. In the night I pass out so don't feel much in the night. However this medicine has caused me gain a lot of weight. I would say I have gained about 25 pounds since starting the medicine."

8 / 10
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  • Slim...
  • Taken for 6 months to 1 year
  • April 8, 2020

For Bipolar Disorder "Finally was able to get back on Quetiapine after adding fiber pills to my diet and I am loving sleep. Spent my whole life not sleeping well or at all lately (was up for almost a week a straight last year). Quetiapine IR was a sure fire way of knocking me out within an hour and staying asleep to well into the morning. Pretty groggy though and had to keep increasing my dose. My Pdoc recently sent the XR version into pharmacy instead and it is rather different. I don’t get knocked out right away which means I can create a better sleep hygiene routine. If I am more relaxed I don’t need to be put to sleep but gradually work my way into it. It does take a minute to fully wake up but I have to say I feel my overall mood remains pretty stable for most of the rest of the day."

10 / 10
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  • KTS
  • Taken for 1 to 6 months
  • May 29, 2018

For Bipolar Disorder "Within 2 months, at a dose of 300mg, it completely changed my life. I have been on many meds and combinations for 20 years, but this (along with much soul- searching, personal responsibility and facing truth, therapy, and DBT skills) has stabilized my Bipolar I and almost cured by borderline personality disorder. I had resigned myself to a difficult and tragic life before this happened. I was inspired to move to a single med, because I was a long time user of Lithium, SSRI, Lamictal combo and wanted to try for a baby. This ended up giving me new life- my own."

10 / 10
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  • royal...
  • Taken for 5 to 10 years
  • October 21, 2014

For Bipolar Disorder "Seroquel XR has changed my life! I tried regular Seroquel and it's like having your head in a bucket. The XL version feels like a completely different medicine. I take 100 mg at night. I wake up refreshed, happy, eager to start my day, I also take Lamictal 300 mg in the morning. No side effects from either medicine. I have been on both for about 7 years. I have been depressed once in that time and it was situational."

10 / 10
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  • Hayle...
  • Taken for 1 to 6 months
  • January 21, 2016

For Bipolar Disorder "This medication has been a real life-saver. I had struggled with heavy depressions interspersed with hypomania for a few years before I was eventually diagnosed with Bipolar 2 Disorder, for which I was prescribed this. The initial 50mg did nothing except be an overrated sleep pill, but the boost to 300mg for bipolar depression helped begin to mellow me out, and a few weeks later I was starting to experience a life free of devastating mood swings. I've read horror stories online, but I experienced nothing of the sort (actually *lost* weight in the past few months). It's a shame there's risks with long-term use, I would happily take this forever otherwise - these past few months have been nice and happy and productive for me thanks to this."

9 / 10
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  • Emma
  • Taken for 1 to 2 years
  • April 30, 2013

For Depression "I was put on 25mg of Seroquel at age 15 due to major depression. I agree with the previous comment made, even on such a low dose I also feel I'm in a chemical straight jacket. I have trouble thinking straight, I can't concentrate for over 15 minutes, my sleep is average - it's extremely hard to wake up. I also find I'm so much more angrier and impulsive, I stutter and can't form words, as well as shaking uncontrollably in my legs when I get anxious. I also get headaches or even at least twice per week. However, my family and close friends have noticed a considerable improvement in my mental health eg suicidal thoughts have almost stopped completely and an increase in more 'happy Emma days'. Such a strong, powerful and dangerous med"

7 / 10
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  • Blixa
  • Taken for less than 1 month
  • December 27, 2019

For Major Depressive Disorder "Have had major depression and major depressive episodes over 45 years. Have tried various SSRI,s . Seroquel is the best so far helped me significantly with one 25mg dose. Where the SSRI,s did not seem to help much at all after months of use. Prozac, Zoloft, Effexor. Side effects seem to be minor except it does make me sleep a lot. A LOT. up to 10 hours a day. Deep sleep not just REM sleep. Works extremely well for me. Although I try to use it only when I need it. In short periods of 2 weeks or so and then see if I still require it. Very effective. I can honestly say this drug saved me from the edge of desperation and suicide."

8 / 10
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  • Anonymous
  • May 3, 2010

For Bipolar Disorder "At 41, I simply couldn't take the depression, the mania, the ADD or the severe anxiety attacks anymore. I finally went to the doctor and she put me on Seroquel XR starting at 50mg for 4 days, then 100mg for 4 days and now the maintenance dosage of 150mgs. It has honestly changed my life and saved my marriage. My brain seems to function normally now. My nearly constant suicide thoughts are gone and I can concentrate on tasks for more than 15 seconds at a time. I would rather have a healthy appetite than feeling nauseous so that side effect only boosts my moods. The only thing I don't like is my dreams are VIVID but not in a nightmare sort of way. I've begun dreaming in color which is also new. I can certainly live with that..."

10 / 10
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  • lynnpl
  • Taken for less than 1 month
  • December 29, 2012

For Bipolar Disorder "I've been in and out of mental health clinics for a long time..just trying to find something to slow my racing thoughts and make me feel like life is bearable. I've taken benzodiazepines..only to become drug seeking and take too many and need early refils, thereby being forced by prescriber to wean off. Done SSRI's with no effect whatsoever. Remeron made me gain 40 pounds in like 2 months time and didn't help me sleep. Marijuana made me paranoid. I just started some new therapy and was diagnosed with bipolar 2 and post traumatic stress disorder. She gave me Seroquel XR and my mind is calm and I sleep good on it. I'm still on a pretty low dose..going up to 100mg tonight and then 150mg on 2 days. Just hope I don't gain weight but so far I feel productive and my mind is quiet."

8 / 10
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49 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.