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Seroquel XR User Reviews & Ratings (Page 4)

Seroquel XR has an average rating of 7.1 out of 10 from a total of 205 reviews on Drugs.com. 62% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Seroquel XR

  • Eeyore
  • Taken for 6 months to 1 year
  • March 21, 2015

For Bipolar Disorder "I was recently diagnosed with bipolar and began taking 25-50mgs a night to aid insomnia because at the time I felt relatively well. I appear to be one of the few to embrace the side effect of increased appetite, when I'm manic, depressed or even the slightest bit anxious my appetite disappears. I can go weeks without feeling the need to eat and I love eating! I used to smoke alot of pot to help with my appetite and racing thoughts. I'm now taking 150mg XR at night as I'm currently having a mixed episode. It helps quieten my mind and slows me down a little but I don't feel in any way zombified, at night soon after taking I get sleepy but that's about it!"

7 / 10
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  • Bueler
  • November 7, 2011

For Depression "The first night I took this medication, I almost ran out of breath before climbing the stairs from the basement to my room (it's as if my respiratory system was somewhat repressed). It also caused some chest/heart pain. On the other hand, I slept well for those two nights. The side effects may be more dangerous than one's condition. Please be careful."

5 / 10
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39 Report
  • SuzieQ
  • Taken for less than 1 month
  • June 26, 2012

For Insomnia "My Dr gave me a sample of this medicine to try and it works good, however it takes me a while to fall asleep and it gave me a hangover effect the next day! Liked the sleep it gave me but I had a hard time waking up the next day."

6 / 10
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37 Report

Frequently asked questions

  • Anonymous
  • Taken for 6 months to 1 year
  • July 9, 2012

For Paranoid Disorder "Seroquel XR worked for me better than the Seroquel. From my understanding the XR is an extended release vs the regular Seroquel. My paranoid thoughts have completely gone away except for the normal paranoia that everyone has of people sometimes talking about them. It also gives me a lot of energy during the day and I do not have to take naps. I have tried Abilify and other medicines, but none seem to work as well as the Seroquel XR."

9 / 10
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  • Anonymous
  • April 10, 2009

For Depression "I was put on this medicine very aggressively (200mg, quickly upped to 400mg) after a suicide attempt. As an antidepressant it is more effective than the first line medications like citalopram. And will help with sleep and a lack of hunger. However I absolutely hate the side effects. It is often said that antipsychotics "steal your soul" or act like a "mental prison". I would have to agree. To begin with this was fine, with severe depression I was happy to take any way out. However after about 6 months of this I decided enough was enough. Now I'm off it my personality is back."

6 / 10
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Are you taking this medicine?

  • Daisy
  • April 6, 2015

For Bipolar Disorder "At first I hated this medication, made me really tired, feelings of non reality and weight gain. The doctor who put me on it said to wait and give it a chance. I'm glad I did. I use it to sleep at night, at some point I will reduce it but it's great for now. I have very restful sleeps, but am unable to remember my dreams. I am bipolar and although I am on other medication for it, I believe that Seroquel has been key in my mood stability. I take 100 mg every night, and 25 mg PRN for anxiety if needed. Although I get tired on it, it does slow down my thoughts."

8 / 10
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  • 55 fe...
  • October 17, 2009

For Depression "It seems to be very helpful for my depression, anxiety, adult ADD and overall mood. Seroquel XR also seems to have no noticeable side effects and I sleep great. I've been taking 2 of the 300mg, in the evening, now for 2 months."

9 / 10
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  • senua...
  • March 23, 2011

For Bipolar Disorder "I suffer from bipolar1, OCD, very severe anxiety, and post traumatic stress disorder. I had been in a mental hospital and had taken so many medicines. I could never stop thinking to the point where I stayed awake all night. Mood swings, temper, just raving mad ,waiting to be set off. Some medicines worked for a short time, and others just didn't work. So my psychologist put me on Lamictal, but it works very slowly and you have to start it on a low dose and work your way up. I had taken it before, but my other doctor left and every other doctor wanted to put me on Lithium but I said no because I have Lupus. But when he put me on Seroquel XR, well that's when things began to look a little bit brighter. It does make you sleepy, but its a great medicine, at least for me anyway. Hope this helps."

9 / 10
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  • txff
  • March 9, 2010

For Bipolar Disorder "Seroquel XR has been a blessing for me. I currently take 600 mg at night. I have suffered from terrible insomnia but with this medicine. I actually get some sleep at night. As far as anxiety goes, it works wonders for me. It totally wiped out my anxiety and I was able to get off of Lithium. In my opinion, it works wonderful for mania, but I wish it helped a little more with my depression. I take 10mg of Prozac to boost that. I did gain some weight but the benefits outweigh this problem. Overall, I think it is a wonderful medicine. I would recommend it highly."

9 / 10
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  • Eliza...
  • November 28, 2014

For Major Depressive Disorder "Seroquel for depression isn't heard of much. I'm on it, and yes at first it was horrible. Head spins and just like motion sickness. But I was advised to stick it out and did. Approx 6 weeks it settled down. I take it for BiPolar, the racing mind, no sleep or little sleep. With Seroquel, I sleep a nights rest. My mind isn't active at all. I'm on 300mg. A bit tired of a morning, but if you are up early, which can be hard, the effects wear off, sooner. I won't swap to any other, I tried Zyprexa but, I'm sticking with Seroquel."

9 / 10
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  • vanil...
  • Taken for 1 to 6 months
  • September 13, 2016

For Bipolar Disorder "Have been on Seroquel XR 25mg (once before bed) for about 6 months now and my life has completely changed for the better. Yeah, the weight gain is a pain but its a small price to pay for normality. Social anxiety / severe insomnia has not been an issue for months!! Am finally myself again. Have tried other antipsychotics but nothing works as well as this one. Only downside is an insatiable appetite - but you can minimize weight gain by substituting with fruits etc, which is what Im currently doing."

8 / 10
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25 Report
  • mom
  • Taken for 1 to 6 months
  • October 19, 2012

For Bipolar Disorder "I have had a negative experience on Seroquel. I do not want this to deter anyone from taking it, as everyone's reaction and experience on this medicine is subjective; I just want to put this out there for anyone who might be experiencing similar symptoms and reactions and may be hesitant to say it and to just relate my own experience. I am Bipolar 2 and have untreated ADHD due to the ADHD medicines causing manic episodes. I started Seroquel 2 months ago when I was having a bout of insomnia. I should state that I was on Wellbutrin, Lamictal, and Paxil, and was feeling good. I was productive during the day and upbeat. I was prescribed Seroquel for the insomnia and taken off all the other except Lamictal. I am now a "zombie", depressed, sleepy 24/7."

1 / 10
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  • Gastr...
  • Taken for 2 to 5 years
  • May 20, 2017

For Depression "I was on this medication for around 3 years at different doses, anywhere from 50 mgs to 600 mgs. It was a very good medicine and helped a lot with my anxiety and depression and really calmed me down and was very helpful, but the weight gain was a killer. I would try to go off over and over and would have to keep going back to it because I would be in such bad shape without it. I had a love/hate relationship with it. I became pre-diabetic while on it. I finally was able to go off and stay off at one point. It's a great drug, but the side effects are horrible as far as weight gain."

8 / 10
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  • Cyenc...
  • Taken for 2 to 5 years
  • April 8, 2015

For Bipolar Disorder "For years I took seroquel in various doses throughout the given day. I was prescribed Seroquel XR about 3 years ago for Anxiety and Bipolar l. Since then it has been very effective. I did not gain weight at all. The only drawback is it does cause dizziness and sleepiness. Therefore, I sometimes opt to take it later than prescribed 7:30pm instead of 6."

10 / 10
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  • tracy
  • January 29, 2021

For Bipolar Disorder "Took Seroquel XR for 11 months for depression, bipolar 2. Had rare side effect. This drug causes tooth caries and gum disease. I had to have all 24 of my teeth pulled out. It was devastating. Also difficult to convince the doctor of the problem. Luckily I read the packet inserts."

1 / 10
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  • Dan
  • Taken for 6 months to 1 year
  • July 17, 2021

For Depression "I have been on the Seroquel XR 50 mgs and it absolutely works better than anything I have ever taken for anxiety. And I've taken every SSRI under the sun, valium, clonidine, gabapentin, and vistaril all in the past. This medication is a life saver. It does make me feel drowsy 3-4 hours after taking it so it should be taken around dinner time. My doc first started me on it first thing in the morning and I was dozing off by noon. But other than that it has been a lifesaver. Almost no anxiety, I sleep better, my appetite is good, my mood is good & confident. For me it even helps to relax my muscles. I'm so glad my doc took a chance and prescribed this medication off-label for my anxiety. It has given me a new lease on life."

10 / 10
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  • Patient...
  • Taken for 1 to 6 months
  • April 29, 2017

For Bipolar Disorder "I don't understand all the negative reviews. For me this pill has worked well. It's calmed me right down and has been blissful at moments. It's expensive unfortunately. As for weight gain, I've noticed that it's pretty neutral... Granted I'm weaning off of Zoloft as well so who knows but I find with medications with 'weight gain' as a side effect just trying your hardest to eat a well balanced diet will prevent it. It's too easy to give up and say oh well I'm gonna get fat - - it's very much not the case. Don't give up, if you're bipolar like me there's a chance you can do a lot with your brain so give it a shot and take your life back. I think much more clearly and am more productive. The overwhelming tiredness subsided after one week."

9 / 10
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  • KRCROX
  • January 8, 2012

For Generalized Anxiety Disorder "I loved how the XR worked for me. I was on 50mg at night. Was a 30 day trial to see if it would help me, it did. My GP gave me the XR then my psychiatrist switched me to the IR 25mg so I could take either 1 or 2 pills depending how I felt. That seemed to be working okay but I had another anxiety attack and it has been 5 days since and I am still not recovered. Tonight I am going to take the XR and see what tomorrow brings. Luckily I do go to my Dr. as well. I am sure that I will feel better tomorrow as I felt great the day after my first XR dose."

9 / 10
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  • Anony...
  • June 6, 2016

For Bipolar Disorder "I really noticed a negative difference when comparing the XR version to the regular Seroquel. It took longer to kick in and made me so drowsy at work that I felt like I was drunk. I think I was taking 100-200 mg. When I went back to regular Seroquel, 100-200 mg put me to sleep fast and made a difference in stabilizing my mood without me feeling too drowsy to function the next day."

4 / 10
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  • Anonymous
  • August 25, 2011

For Bipolar Disorder "I used to be so paranoid I couldn't even sleep at night. I would go into manic episodes and be in lala land for days until this wonderful pill came into my life. I have never felt better. I just never felt so good I'm happy."

10 / 10
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  • shortie
  • April 9, 2016

For Bipolar Disorder "I was prescribed seroquel xr for Bipolar depression My dr started me on 50mg and I am gradually increasing the dosage its been about 4 weeks and I am currently taking 200 mg I will agree that it has helped the hopelesness feelings and suicidal thoughts Which is a plus but the zombie like feeling and dry mouth are tough I have a job that requires constant activity its hard to keep up have to definitely slow down My Dr advised me that these side affects are all normal and eventually I will get used to it can't wait for this to happen"

7 / 10
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  • Befor...
  • February 7, 2019

For Bipolar Disorder "I've taken this med in the past. I required a higher dosage because I was feeling paranoid. A few months ago, I weaned myself off of it, but I took other meds. I started to lose weight, and I was feeling healthy physically, but mentally my mind was active. I don't feel paranoia like I did in the past, but lately I'm taking a low dose of 150mg compared to 600mg several months ago. If I take it too soon before bedtime, I tend to feel groggy in the morning, and it takes me 9 hours of sleep. It can cause weight gain, and diabetes. Make sure you have your blood sugar monitored every 3 months. Eat small snacks, less carbs and exercise. Healthy sleep make you happy."

8 / 10
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16 Report
  • Sleep...
  • March 9, 2012

For Insomnia "Seroquel was the only thing that knocked me out. I've been on it for 8 months, but have gained 50 lbs, which I have attributed to Seroquel. Not to mention that diet and exercise aren't cutting it to lose the weight. Wish I could find something that could make me sleep as well as Seroquel without the weight gain."

6 / 10
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30 Report
  • Nessa...
  • March 15, 2017

For Bipolar Disorder "I'm 24 yrs old, have severe RA and been talking seroquel XR at 300 milligrams a night for nearly a year.... I was diagnosed bipolar 2 years ago but had so much trouble finding a psychiatrist who was caring enough to listen to me (like a psychologist AND work as a psychiatrist, pill pusher) so my diagnosis went treated and untreated on and off for a while. BUT since I've been seeing my doctor regularly and she seems to genuinely care I've trusted her judgment with her diagnosis and what she thought would help me most.... besides the weight gain, honestly I feel much more stable & I can deal with the world around me as I see it and haven't had any serious depressive episodes or hypomania. This medication has worked wonders for me."

9 / 10
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  • Redfoxy
  • Taken for 6 months to 1 year
  • March 14, 2020

For Schizoaffective Disorder "Hello, I have been taking seroquel XR for just over a year now, started with 25mgs dose, now up to 200mgs dose. I found that my thoughts are controllable, relatively a good sleeping aid. Just be careful not to eat after an hour or so of taking certain brands of this medication. Seroquel XR blue/white pack 100mgs makes anything hard to swallow even water. Best to go straight to bed. Would like to try managing my own emotions and thoughts one day without medication. I hope for everyone who struggles. Thank you and good luck!"

5 / 10
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13 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.