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Olanzapine / samidorphan User Reviews & Ratings

Brand names: Lybalvi

Olanzapine / samidorphan has an average rating of 7.9 out of 10 from a total of 8 reviews on Drugs.com. 67% of reviewers reported a positive experience, while 0% reported a negative experience.

Reviews for Olanzapine / samidorphan

  • Viole...
  • Taken for less than 1 month
  • April 30, 2022

Lybalvi (olanzapine / samidorphan) for Bipolar Disorder "Lybalvi has reworked olanzapine into a masterpiece. The buzz is that when sandimorphan is approved as a standalone med, it will treat personality disorders and addictions. For my Bipolar 2 Disorder, it has shaved off my nervous edge. I like myself more. It offers the mania-busting calm of olanzapine but makes me feel like I belong in this world. My doctor has once again improved my life immeasurably by knowing what to prescribe."

10 / 10
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26 Report
  • Miracle...
  • Taken for 1 to 6 months
  • August 24, 2023

Lybalvi (olanzapine / samidorphan) for Bipolar Disorder "I like this medication. I was not sure I wanted to take it because Zyprexa caused serious weight gain. I gained about 13-15 lbs in a month, and that’s my only complaint. My irritability is much better. I have lost my libido, completely disinterested, and that would be why I stop this medication. Samidorphan is related to Naltrexone, by the way, so if you take medication for pain management or enjoy drinking alcohol, you may want to take another medication as it acts like an antagonist to the opioid receptors."

8 / 10
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8 Report
  • Rocket
  • Taken for 6 months to 1 year
  • December 11, 2023

Lybalvi (olanzapine / samidorphan) "I've had some constipation and dry mouth, but no other serious side effects so far. I have lost 25 pounds in about 6 months. I have noticed some restlessness and anxiety but my doctor is treating that along with insomnia with a different medication. Lybalvi has been great helping manage my bipolar symptoms since coming off of lithium after being diagnosed with CKD. I am on 20mg/10mg dose and feeling stable."

8 / 10
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4 Report
  • Sarah...
  • Taken for 1 to 6 months
  • April 25, 2022

For Schizophrenia "It curbes my appetite. I haven’t had any severe side effects except occasional twitching, dizziness and drowsiness. Since being on this medication I’ve noticed the auditory and visual hallucinations have gone to a minimal. There are some days better than others if I don’t take Lybalvi on time such as it’s hard to wake up in the morning and I have to slowly get up from the bed until the dizziness goes away. I take it at night right at bedtime. Overall this has helped with controlling my mood swings. I don’t feel aggressive, I don’t feel depressed, I don’t feel manic."

8 / 10
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7 Report
  • OKe
  • Taken for 6 months to 1 year
  • November 12, 2023

Lybalvi (olanzapine / samidorphan) "Not good for sleep. I suffered a traumatic brain injury 30 years ago and have a lot of problems with sleep. This drug seems to worsen my insomnia. I'm very active and have a difficult time stopping. I have had no hallucinations and voices in my head have stopped. I really miss sleep. The stopping of hallucinations and voices in my head is why I stay on the medication. If you need to be rested because of your daily activities, I would not recommend."

8 / 10
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1 Report

Are you taking this medicine?

  • emexj...
  • Taken for less than 1 month
  • February 7, 2023

For Bipolar Disorder "I was really excited to try this one out since olanzapine had a decent therapeutic effect for me previously, but the side effects were horrible. This new drug combination is supposed divert the weight gain side effect, which should have also had some impact on glucose, lipids, and cholesterol. Unfortunately for me, I am still gaining weight as fast as I did one regular olanzapine without the samidorphan. The somnolence and nausea were pretty bad. The insatiable appetite probably did not help either. I am meeting with my doctor this week to discuss another alternative."

6 / 10
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2 Report
  • Bayle...
  • Taken for 1 to 6 months
  • April 29, 2024

Lybalvi (olanzapine / samidorphan) for Bipolar Disorder "I was on the lowest dose of Lybalvi and was switched to it from Olanzapine, because I was told that Lybalvi had the Olanzapine with the Sanadorphin to combat weight gain. While the Lybalvi did help to stabilize my mood and helped with my motivation, I did feel tired and had trouble waking up. Not only that, but I got to my heaviest weight ever because I always felt hungry. People claim this medication is the best, but I will never forget how its side effects ruined my confidence."

7 / 10
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  • Curtis...
  • Taken for 1 to 6 months
  • September 28, 2023

Lybalvi (olanzapine / samidorphan) for Schizophrenia "I'm in the second month of taking the drug. I was on Zyprexa alone for five years. This stuff has a punch. Don't drive cars. Hopefully I can get over the sedation in another couple weeks."

6 / 10
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10 Report
  • Ronald
  • Taken for 1 to 6 months
  • December 5, 2023

Lybalvi (olanzapine / samidorphan) for Schizophrenia "Been on it for 5 months now. Was on Seroquel, but it stopped working. Great medication, it works wonders."

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6 Report
  • lynette
  • Taken for 1 to 2 years
  • November 16, 2023

Lybalvi (olanzapine / samidorphan) for Bipolar Disorder "Help me focus much better. No more hallucinations. Function and mood every day more calmly. My eating is less than before."

10 / 10
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5 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.