Repaglinide

Repaglinide is used for:

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Managing type 2 (non-insulin-dependent) diabetes. It is used in addition to diet and exercise to lower blood sugar in adults who cannot manage with diet, exercise, or diabetic medications alone. It may be used with other diabetes medicines.

Repaglinide is a meglitinide antidiabetic. It works to lower blood glucose (sugar) by stimulating the release of insulin from the pancreas gland. Repaglinide does not work in type 1 (insulin-dependent) diabetes, because in this condition the pancreas gland is not capable of making or releasing insulin.

Do NOT use Repaglinide if:

• you are allergic to any ingredient in Repaglinide
• you have type 1 diabetes (insulin-dependent diabetes) or have elevated ketone levels due to diabetes
• you are also taking gemfibrozil

Contact your doctor or health care provider right away if any of these apply to you.

Before using Repaglinide :

Some medical conditions may interact with Repaglinide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription medicine, nonprescription medicine, herbal preparation or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of acidosis, kidney disease, or liver disease

Some MEDICINES MAY INTERACT with Repaglinide . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Rifampin because it may decrease Repaglinide 's effectiveness
• Beta blockers (eg, propranolol), gemfibrozil, imidazoles (eg, ketoconazole), macrolides and ketolides (eg, erythromycin, azithromycin), monoamine oxidase (MAO) inhibitors (eg, phenelzine), quinolones (eg, ciprofloxacin), or salicylates (eg, aspirin) because the risk of side effects, such as low blood sugar, may be increased
• Insulin because it may increase the risk of Repaglinide 's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Repaglinide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Repaglinide :

Use Repaglinide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Repaglinide by mouth at least 15 to 30 minutes before each meal. If you skip a meal, do not take the dose for the skipped meal. If you add an extra meal, take an extra dose with that meal.
• If you miss a dose of Repaglinide , skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use Repaglinide .

Important safety information:

• Fever, injury, infection, or surgery may affect your diabetes control. If any of these occur, check with your doctor.
• Diabetes patients - Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take Repaglinide exactly as prescribed, tell your doctor.
• Diabetes patients - Repaglinide may lower your blood sugar levels. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
• Follow the diet and exercise program given to you by your health care provider.
• Tell your doctor or dentist that you take Repaglinide before you receive any medical or dental care, emergency care, or surgery.
• Lab tests, such as liver and kidney function tests, fasting blood sugar, glycosylated hemoglobin, or complete blood cell counts, may be performed while you take Repaglinide . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Repaglinide while you are pregnant. It is not known if Repaglinide is found in breast milk. Do not breast-feed while you are taking Repaglinide .

Possible side effects of Repaglinide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in vision; diarrhea; headache; increased heartbeat; increased hunger; joint or back pain; nasal or chest congestion; nervousness; sinus inflammation; sweating; tiredness; tremor.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA- 1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include confusion; dizziness; fatigue; loss of consciousness; nausea; personality changes; seizure; shakiness.

Store Repaglinide at room temperature, between 59 and 77 degrees F (15 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Repaglinide out of the reach of children and away from pets.

General information:

• If you have any questions about Repaglinide , please talk with your doctor, pharmacist, or other health care provider.
• Repaglinide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Repaglinide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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