Repaglinide

Pronunciation

Generic Name: repaglinide (re-PAG-li-nide)
Brand Name: Prandin

Repaglinide is used for:

Treating type 2 (non-insulin-dependent) diabetes in patients who cannot control blood sugar levels by diet and exercise alone. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

Repaglinide is a meglitinide antidiabetic. It works to lower blood glucose (sugar) by stimulating the release of insulin from the pancreas gland. Repaglinide does not work in type 1 (insulin-dependent) diabetes, because in this condition the pancreas gland is not capable of making or releasing insulin.

Do NOT use repaglinide if:

  • you are allergic to any ingredient in repaglinide
  • you have type 1 diabetes (insulin-dependent diabetes)
  • you have certain severe problems associated with diabetes (eg, diabetic ketoacidosis, diabetic coma)
  • you are taking gemfibrozil or NPH insulin

Contact your doctor or health care provider right away if any of these apply to you.

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Before using repaglinide:

Some medical conditions may interact with repaglinide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have adrenal, pituitary, liver, or kidney problems, or if you have a history of high blood acid levels (acidosis)
  • if you drink alcohol, have very poor health, have a high fever, have a severe infection or injury, or have had poor nutrition
  • if you will be having surgery

Some MEDICINES MAY INTERACT with repaglinide. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • NPH insulin because the risk of certain heart problems (eg, myocardial ischemia, chest pain) may be increased
  • Anticoagulants (eg, warfarin), beta-blockers (eg, propranolol), chloramphenicol, cyclosporine, deferasirox, gemfibrozil, imidazoles (eg, itraconazole, ketoconazole), macrolides (eg, clarithromycin, erythromycin), mifepristone, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), montelukast, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), probenecid, salicylates (eg, aspirin), sulfonamides (eg, sulfamethoxazole), telithromycin, or trimethoprim because the risk of side effects, such as low blood sugar, may be increased
  • Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), isoniazid, nicotinic acid, phenothiazines (eg, chlorpromazine), phenytoin, sympathomimetics (eg, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high blood sugar may be increased
  • Insulin because it may increase the risk of repaglinide's side effects
  • Barbiturates (eg, phenobarbital), carbamazepine, or rifamycins (eg, rifampin) because they may decrease repaglinide's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if repaglinide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use repaglinide:

Use repaglinide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take repaglinide by mouth at least 15 to 30 minutes before each meal. If you skip a meal, do not take the dose for the skipped meal. If you add an extra meal, take an extra dose with that meal.
  • If you miss a dose of repaglinide, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use repaglinide.

Important safety information:

  • Dizziness may occur while you are taking repaglinide. This effect may be worse if you take it with alcohol or certain medicines. Use repaglinide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink large amounts of alcohol while you use repaglinide. Talk to your doctor or health care provider before you drink alcohol while you use repaglinide.
  • Follow the diet and exercise program given to you by your health care provider.
  • Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take repaglinide exactly as prescribed, tell your doctor.
  • Repaglinide may lower your blood sugar levels. Low blood sugar may be more likely to occur if you skip a meal, exercise heavily, or drink alcohol. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
  • It may be harder to control your blood sugar during times of stress such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor.
  • Tell your doctor or dentist that you take repaglinide before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including fasting blood sugar and hemoglobin A1c levels, may be performed while you take repaglinide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use repaglinide with caution in the ELDERLY; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in elderly patients.
  • Repaglinide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking repaglinide while you are pregnant. It is not known if repaglinide is found in breast milk. Do not breast-feed while you are taking repaglinide.

Possible side effects of repaglinide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; joint or back pain; sinus pain or pressure; symptoms of upper respiratory tract infection (eg, cough, mild sore throat, runny or stuffy nose, sneezing).

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fever, chills, or persistent sore throat; low blood sugar symptoms (eg, anxiety; fainting; fast heartbeat; increased hunger; light-headedness; severe or persistent dizziness, drowsiness, or headache; tremors; unusual sweating; weakness; vision changes); unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include seizures; symptoms of low blood sugar (eg, increased hunger or sweating, fast heartbeat, anxiety, dizziness or headache, tremors, chills, vision changes).

Proper storage of repaglinide:

Store repaglinide below 77 degrees F (25 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep repaglinide out of the reach of children and away from pets.

General information:

  • If you have any questions about repaglinide, please talk with your doctor, pharmacist, or other health care provider.
  • Repaglinide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take repaglinide or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about repaglinide. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to repaglinide. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using repaglinide.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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