Ranibizumab

Generic Name: ranibizumab (RA-ni-BIZ-ue-mab)
Brand Name: Lucentis

Ranibizumab is used for:

Treating neovascular (wet) age-related macular degeneration (AMD). It is also used for treating a type of eye problem known as macular edema that is caused by certain problems (eg, diabetes, retinal vein occlusion [RVO]). It may also be used for other conditions as determined by your doctor.

Ranibizumab is a selective vascular endothelial growth factor (VEGF) antagonist. It works by decreasing the growth of certain cells in the eye. It also helps to keep blood vessels in the eye from leaking and decreases the formation of new blood vessels in the eye. This slows or stops wet AMD and macular edema.

Do NOT use ranibizumab if:

  • you are allergic to any ingredient in ranibizumab
  • you have an infection in or around the eye

Contact your doctor or health care provider right away if any of these apply to you.

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Before using ranibizumab:

Some medical conditions may interact with ranibizumab. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if your condition has also been treated with a certain type of light therapy (verteporfin photodynamic therapy)
  • if you have a history of glaucoma or increased pressure in the eye, or other eye problems

Some MEDICINES MAY INTERACT with ranibizumab. However, no specific interactions with ranibizumab are known at this time.

Ask your health care provider if ranibizumab may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ranibizumab:

Use ranibizumab as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Ranibizumab is given as an injection into the eye at your doctor's office, hospital, or clinic.
  • Do not use ranibizumab if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Ranibizumab is for injection into the eye only.
  • If you miss a dose of ranibizumab, contact your doctor right away.

Important safety information:

  • Ranibizumab may cause vision changes. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to ranibizumab.
  • If you develop eye pain or redness, eye or eyelid swelling, sensitivity to light, or vision changes (eg, decreased vision), contact your doctor right away.
  • Lab tests, including eye exams and eye pressure measurements, may be performed before and after you receive ranibizumab. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Ranibizumab should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if ranibizumab can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using ranibizumab while you are pregnant. It is not known if ranibizumab is found in breast milk. If you are or will be breast-feeding while you use ranibizumab, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of ranibizumab:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; dry eye; eye discomfort; feeling of something in the eye; headache; increased tear production; nausea; nose or throat irritation; seeing floaters or spots.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest, jaw, or arm pain; confusion; decreased vision or other vision changes; eye or eyelid swelling; eye pain, pressure, redness, bleeding, or discharge; fainting; fever, chills, or persistent sore throat; one-sided weakness; sensitivity to light; shortness of breath; slurred speech; sudden, severe nausea or vomiting; unusual sweating or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include eye swelling. Ranibizumab may be harmful if swallowed.

Proper storage of ranibizumab:

Ranibizumab is handled and stored by a health care provider. Keep ranibizumab out of the reach of children and away from pets.

General information:

  • If you have any questions about ranibizumab, please talk with your doctor, pharmacist, or other health care provider.
  • Ranibizumab is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take ranibizumab or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about ranibizumab. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ranibizumab. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using ranibizumab.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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