Generic Name: dipyridamole (dye-peer-ID-a-mole)
Brand Name: Persantine
Persantine is used for:
Preventing blood clots after heart valve surgery. It is used in combination with anticoagulants (eg, warfarin). It also may be used for other conditions as determined by your doctor.
Persantine is a platelet inhibitor. How it works is not fully understood. It is thought to work by increasing the levels of a body chemical (adenosine), which widens blood vessels and decreases platelet activity.
Do NOT use Persantine if:
- you are allergic to any ingredient in Persantine
Contact your doctor or health care provider right away if any of these apply to you.
Before using Persantine:
Some medical conditions may interact with Persantine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have severe heart disease, chest pain, low blood pressure, or liver problems, or you have recently had a heart attack
Some MEDICINES MAY INTERACT with Persantine. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Adenosine because the risk of its side effects, including low blood pressure and irregular heartbeat, may be increased by Persantine
- Anticholinesterases (eg, neostigmine) because their effectiveness may be decreased by Persantine
This may not be a complete list of all interactions that may occur. Ask your health care provider if Persantine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Persantine:
Use Persantine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Persantine by mouth on an empty stomach at least 1 hour before or 2 hours after eating. It may be taken with food if it upsets your stomach.
- If you miss a dose of Persantine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Persantine.
Important safety information:
- Persantine may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Persantine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Persantine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Tell your doctor or dentist that you take Persantine before you receive any medical or dental care, emergency care, or surgery.
- Use Persantine with caution in the ELDERLY; they may be more sensitive to its effects.
- Persantine should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Persantine while you are pregnant. Persantine is found in breast milk. If you are or will be breast-feeding while you use Persantine, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Persantine:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; dizziness; flushing; headache; itching; stomach pain; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fast heartbeat; hepatitis; pounding in the chest; swelling of throat.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include depression; diarrhea; low blood pressure; vomiting.Proper storage of Persantine:
Store Persantine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Persantine out of the reach of children and away from pets.
- If you have any questions about Persantine, please talk with your doctor, pharmacist, or other health care provider.
- Persantine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Persantine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Persantine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Persantine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Persantine.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More Persantine resources
- Persantine Prescribing Information (FDA)
- Persantine Advanced Consumer (Micromedex) - Includes Dosage Information
- Persantine Concise Consumer Information (Cerner Multum)
- Persantine Monograph (AHFS DI)
- Dipyridamole Prescribing Information (FDA)
- Dipyridamole Professional Patient Advice (Wolters Kluwer)