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Dipyridamole Pregnancy and Breastfeeding Warnings

Dipyridamole is also known as: Persantine, Persantine IV

Dipyridamole Pregnancy Warnings

In one study, therapy with dipyridamole 300 mg and aspirin 150 mg per day was initiated at 13 weeks' gestation in 52 pregnant patients at high risk for preeclampsia and fetal growth retardation. Compared to 50 control patients, women treated with dipyridamole had a lower incidence of preeclampsia, fetal loss, and fetal growth retardation. Abnormal bleeding was absent in both mother and neonate in all cases. In another study, 24 women (30 pregnancies) with a history of fetal growth retardation and placental infarction in previous pregnancies were treated with aspirin 1 to 1.6 mg/kg and dipyridamole 225 mg per day from 16 to 34 weeks' gestation. A control group consisted of 24 women (27 pregnancies) with a similar history. Fetal growth retardation occurred in 13% of pregnancies in the treated group compared to 61% of pregnancies in the control group. No adverse maternal or fetal effects could be attributed to dipyridamole or aspirin. Similar findings have been documented by other studies and case reports. Data on the safety of dipyridamole during the first trimester are limited.

Dipyridamole has been assigned to pregnancy category B by the FDA. Animal studies failed to reveal evidence of teratogenicity. Dipyridamole has been given throughout pregnancy in patients requiring anticoagulation for prosthetic heart valve as well as for the prevention of preeclampsia and intrauterine growth retardation. No malformations have been reported associated with perinatal use of dipyridamole. Dipyridamole should only be given during pregnancy when need has been clearly established.

Dipyridamole Breastfeeding Warnings

Dipyridamole is excreted into human milk in small amounts. There are no reports of adverse events in infants secondary to breast-feeding during dipyridamole administration. The manufacturer recommends that caution be used when giving dipyridamole to nursing women.

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