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Oxaliplatin

Pronunciation

Generic Name: oxaliplatin (ox-AL-i-PLA-tin)
Brand Name: Eloxatin

Oxaliplatin may rarely cause severe and sometimes fatal allergic reactions. These can occur within minutes of administration. Notify your doctor immediately if you experience signs of an allergic reaction such as rash; hives; itching; dizziness; flushing; swelling of your lips, throat, or tongue; excessive sweating; sudden cough; chest pain; confusion; shortness of breath; trouble breathing or swallowing; wheezing; or fainting.


Oxaliplatin is used for:

Treating advanced cancer of the colon or rectum in certain patients. It is usually used in combination with other medicines.

Oxaliplatin is an antineoplastic. It works by killing cancer cells and slowing tumor growth.

Do NOT use oxaliplatin if:

  • you are allergic to any ingredient in oxaliplatin or to another platinum product (eg, cisplatin, carboplatin)
  • you have certain lung problems (eg, pulmonary fibrosis, interstitial lung disease)
  • you have taken or will be taking palifermin within 24 hours of taking oxaliplatin

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2014 Update: First Time Brand-to-Generic Switches

Before using oxaliplatin:

Some medical conditions may interact with oxaliplatin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are able to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney or liver problems, blood problems (eg, anemia), bone marrow problems, or nerve problems
  • if you have a history of lung or breathing problems

Some MEDICINES MAY INTERACT with oxaliplatin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin) because the risk of bleeding may be increased
  • Palifermin because if mouth or tongue sores develop, they may be more severe or last longer
  • Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of oxaliplatin's side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney

This may not be a complete list of all interactions that may occur. Ask your health care provider if oxaliplatin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use oxaliplatin:

Use oxaliplatin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with oxaliplatin. Talk to your pharmacist if you have questions about this information.
  • Oxaliplatin is usually administered as an injection at your doctor's office, hospital, or clinic.
  • Do not use oxaliplatin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • If you spill oxaliplatin on your skin, wash it off right away with soap and water
  • If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects. Also, other medicines may be given before and after therapy with oxaliplatin to help reduce these effects.
  • It is important to take each dose as scheduled. If you must miss a dose, contact your doctor right away.

Ask your health care provider any questions you may have about how to use oxaliplatin.

Important safety information:

  • Oxaliplatin may cause dizziness, tiredness, balance problems, temporary vision loss, or other vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use oxaliplatin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
  • Oxaliplatin may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Oxaliplatin may lower the ability of your body to fight infection. Avoid contact with people who have colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first.
  • Do not receive a live vaccine (eg, measles, mumps) while you are taking oxaliplatin. Talk with your doctor before you receive any vaccine.
  • Some patients using oxaliplatin have developed severe and sometimes fatal lung problems. Tell your doctor right away if you develop a dry cough, or trouble breathing or shortness of breath.
  • Oxaliplatin may cause burning, numbness, pain, or tingling in the hands or feet, or around the mouth or throat. It may also cause jaw tightness, odd feelings in your tongue, joint or eye pain, or chest pressure. Exposure to cold temperatures or cold objects may make these symptoms worse. Avoid drinking cold drinks and ice while receiving oxaliplatin. Cover exposed skin before exposing yourself to cold temperatures or cold objects. Tell your doctor right away if you experience any of these effects.
  • You can reduce sensitivity to cold temperatures or objects by doing the following: cover yourself with a blanket while receiving oxaliplatin; do not breathe deeply when exposed to cold air; wear warm clothing in cold weather at all times; cover your mouth and nose with a scarf or a ski cap to warm the air that goes into your lungs; wear gloves when removing items from the freezer and refrigerator or when touching car doors, mailboxes, or other metal objects; drink fluids warm or at room temperature; drink beverages with a straw; do not use ice chips if you have nausea or mouth sores; do not put ice packs on your body; do not run the air conditioning at high levels in the house or car during hot weather; if you get cold, warm up only the cold part of your body; warm cold hands up with warm water.
  • Oxaliplatin may rarely cause a serious brain problem called reversible posterior leukoencephalopathy syndrome (RPLS). Contact your doctor right away if you experience severe headache, seizures, confusion, problems thinking, or vision changes (eg, blurred vision, loss of vision).
  • Tell your doctor or dentist that you take oxaliplatin before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Oxaliplatin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Women who may become pregnant should use an effective form of birth control while they are using oxaliplatin. Talk with your doctor if you have questions about effective birth control.
  • Lab tests, including complete blood cell counts, kidney function, and liver function, may be performed while you use oxaliplatin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use oxaliplatin with caution in the ELDERLY; they may be more sensitive to its effects, especially diarrhea, dehydration, low potassium levels, fatigue, fainting, and increased risk of infection.
  • Oxaliplatin should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Oxaliplatin may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using oxaliplatin while you are pregnant. It is not known if oxaliplatin is found in breast milk. Do not breast-feed while taking oxaliplatin.

Possible side effects of oxaliplatin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; decreased appetite; diarrhea; dizziness; gas; hair loss; headache; heartburn; hiccups; increased tear production; mild stomach pain; muscle or joint pain; nausea; runny nose; taste changes; tiredness; trouble sleeping; vomiting; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); blood in the urine; calf or leg pain, swelling, redness, or tenderness; change in the amount of urine produced; chest pain or pressure; confusion, slurred speech, or one-sided weakness; cough; coughing up blood; excessive or unusual sweating; fainting; fast heartbeat; flushing; hearing loss; loss of coordination; mental or mood changes (eg, depression); mouth or tongue sores or swelling; nosebleeds; pain, redness, or swelling at the injection site; red, swollen, blistered, or peeling skin; reduced sense of touch; severe or persistent diarrhea or vomiting; severe or persistent dizziness, light-headedness, or headache; severe or persistent tiredness or weakness; shivering; shortness of breath; swelling of the hands, ankles, or feet; symptoms of dehydration (eg, very dry eyes, mouth, or skin; unusual thirst); symptoms of infection (eg, fever, chills, or sore throat; burning or painful urination; pain on swallowing); symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; persistent nausea, stomach pain, loss of appetite); symptoms of low potassium levels (eg, irregular heartbeat, muscle pain or cramps); symptoms of stomach or bowel bleeding (eg, black, tarry stools; vomit that looks like coffee grounds); trouble walking, swallowing, speaking, or performing other daily tasks (eg, writing, buttoning); unusual bruising or bleeding; vision loss or other vision changes; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; mouth or tongue sores or swelling; muscle spasms in the face or throat; numbness, burning, or tingling in the arms, hands, legs, or feet; severe nausea or vomiting; severe or persistent diarrhea or constipation; severe stomach pain; shortness of breath; swollen stomach; symptoms of dehydration (eg, very dry eyes, mouth, or skin; unusual thirst); symptoms of infection (eg, fever, chills, persistent sore throat); trouble breathing; unusual bruising or bleeding; unusual tiredness or weakness; very slow heartbeat; wheezing.

Proper storage of oxaliplatin:

Oxaliplatin is handled and stored by a health care provider. Keep oxaliplatin out of the reach of children and away from pets.

General information:

  • If you have any questions about oxaliplatin, please talk with your doctor, pharmacist, or other health care provider.
  • Oxaliplatin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take oxaliplatin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about oxaliplatin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to oxaliplatin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using oxaliplatin.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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