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Neupogen

Pronunciation

Generic Name: filgrastim (fil-GRA-stim)
Brand Name: Neupogen

Neupogen is used for:

Decreasing the risk of infection in certain patients, including cancer patients who are receiving chemotherapy or a bone marrow transplant. It may also be used for other conditions as determined by your doctor.

Neupogen is a hematopoietic agent. It works by stimulating the production of neutrophils (a type of white blood cells) by bone marrow.

Do NOT use Neupogen if:

  • you are allergic to any ingredient in Neupogen
  • you are allergic to other medicines made using the bacteria Escherichia coli. Ask your doctor if you are not sure

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Neupogen:

Some medical conditions may interact with Neupogen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you think you may be pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are undergoing chemotherapy or radiation therapy
  • if you have leukemia, other blood disorders (eg, myelodysplastic syndrome), an infection of the blood or tissue, or sickle cell disease

Some MEDICINES MAY INTERACT with Neupogen. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Lithium because it may increase the risk of Neupogen's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Neupogen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Neupogen:

Use Neupogen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Neupogen. Talk to your pharmacist if you have questions about this information.
  • Do not shake Neupogen. Shaking may damage Neupogen. If the vial or syringe has been shaken, the solution may appear foamy and it should not be used.
  • Neupogen is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Neupogen at home, a health care provider will teach you how to use it. Be sure you understand how to use Neupogen. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Neupogen if it contains particles, is cloudy or discolored, or if the vial or syringe is cracked or damaged.
  • Use only disposable syringes and needles. Use the syringes and needles only once and dispose of them in a puncture-proof container as instructed by your health care provider.
  • Choose a new site each time you inject Neupogen. Do not inject into an area that is tender, red, bruised, hard, swollen, or has scars or stretch marks.
  • Discard any unused portion of medicine left in the vial or syringe.
  • Continue to use Neupogen for the full course of treatment. Do not miss any doses.
  • Neupogen works best if it is used at the same time each day.
  • If you use Neupogen because you also receive chemotherapy, the last dose of Neupogen should be used at least 24 hours before your next dose of chemotherapy.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Neupogen, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Neupogen.

Important safety information:

  • Neupogen may cause an allergic reaction (rash; hives; itching; swelling of the mouth, face, lips, or tongue; dizziness; fainting; shortness of breath; wheezing; fast heartbeat; sudden increased sweating), usually within 30 minutes after receiving this medication. Contact your doctor immediately if you experience an allergic reaction.
  • Neupogen may not prevent all infections. Contact your doctor right away if you develop signs of an infection (eg, fever; chills; rash; sore throat; diarrhea; pain, redness, or swelling around a cut or sore).
  • You may experience bone or muscle aches while you use Neupogen. These symptoms can usually be relieved by a non-aspirin pain reliever (eg, acetaminophen).
  • Serious and sometimes fatal spleen problems (including spleen rupture) have been reported in patients using Neupogen. Contact your doctor right away if pain occurs in the left upper stomach area or left shoulder tip area.
  • Neupogen may interfere with certain lab tests, including bone-imaging. Be sure your doctor and lab personnel know you are taking Neupogen.
  • Lab tests, including complete blood cell counts, may be performed while you use Neupogen. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Neupogen while you are pregnant. It is not known if Neupogen is found in breast milk. If you are or will be breast-feeding while you use Neupogen, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Neupogen:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bone or muscle pain or ache; headache; nausea; nosebleed; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; coughing up blood; dark, tarry, or bloody stools; dizziness; fainting; fast or irregular heartbeat; fast breathing; fever; left shoulder tip pain; left upper stomach pain; lump, swelling, redness, or bruising at an injection site; severe or persistent headache; severe or persistent tiredness or weakness; shortness of breath; sudden increased sweating; swelling or soreness of the mouth or tongue; unusual bruising or bleeding; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Neupogen:

Store Neupogen in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. If accidentally frozen, allow the medicine to thaw at room temperature. If frozen more than once, the medicine should be thrown away. If Neupogen is left at room temperature for more than 24 hours, it should be discarded. Keep Neupogen out of the reach of children and away from pets.

General information:

  • If you have any questions about Neupogen, please talk with your doctor, pharmacist, or other health care provider.
  • Neupogen is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Neupogen or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Neupogen. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Neupogen. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Neupogen.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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