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Myleran

Generic Name: busulfan (byoo-SUL-fan)
Brand Name: Myleran

Myleran may cause severe and persistent bone marrow depression. Discuss any questions or concerns with your doctor.


Myleran is used for:

Treating the symptoms of chronic myelogenous leukemia.

Myleran is an alkylating agent. It works by slowing down reproduction and growth of certain white blood cells, which helps the body fight leukemia.

Do NOT use Myleran if:

  • you are allergic to any ingredient in Myleran

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Myleran:

Some medical conditions may interact with Myleran. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bone marrow problems, blood problems (eg, porphyria, thalassemia), a head injury, or a history of seizures (eg, epilepsy)
  • if you have undergone chemotherapy or radiation or have previously or are currently taking any other medicines for cancer
  • if you are overweight

Some MEDICINES MAY INTERACT with Myleran. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Acetaminophen, metronidazole, or itraconazole because they may increase the risk of Myleran's side effects
  • Cyclophosphamide because the risk of serious heart side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Myleran may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Myleran:

Use Myleran as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Myleran may be taken with or without food. If nausea or vomiting occurs, it may help to take Myleran on an empty stomach.
  • Myleran works best if it is taken at the same time each day.
  • Drinking extra fluids while you are taking Myleran is recommended. Check with your doctor or nurse for instructions.
  • If you miss a dose of Myleran, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Myleran.

Important safety information:

  • Tell your doctor or dentist that you take Myleran before you receive any medical or dental care, emergency care, or surgery.
  • If nausea, vomiting, or loss of appetite occur, do not stop using your medicine. Ask your doctor, nurse, or pharmacist for ways to lessen these effects.
  • Myleran may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Myleran may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Do not receive a live vaccine (eg, measles, mumps) while you are taking Myleran. Talk with your doctor before you receive any vaccine.
  • Myleran increases the risk of a second cancer in future years. It may also cause a rare but serious lung problem (bronchopulmonary dysplasia with pulmonary fibrosis) within months to years after treatment with Myleran. Talk with your doctor if you have questions about your risk for these problems.
  • A serious and sometimes fatal heart problem has happened with some people taking Myleran. Most of the time, stomach pain and vomiting happened before the heart problem. Discuss any questions or concerns with your doctor.
  • Serious and sometimes fatal liver problems have happened with Myleran. Call your doctor right away if you have symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, right-upper stomach pain, unusual tiredness, yellowing of the skin or eyes).
  • Use birth control that you can trust to prevent pregnancy during care and for some time after care ends. Talk with your doctor to see how long to use birth control after you stop Myleran.
  • If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for some time after care ends. Use birth control that you can trust. Talk with your doctor to see how long to use birth control after you stop Myleran.
  • Myleran may cause you to not able to get pregnant. Discuss any questions or concerns with your doctor.
  • Myleran may affect sperm in men. This may affect being able to father a child. Discuss any questions or concerns with your doctor.
  • Lab tests may be performed while you use Myleran. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: Myleran may cause harm to the fetus. Avoid becoming pregnant while you are taking Myleran. If you suspect you may be pregnant, contact your doctor right away. It is unknown if Myleran is excreted in breast milk. Do not breast-feed while taking Myleran.

Possible side effects of Myleran:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Change in color of skin; dry mouth, nose, and throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or pressure; missed menstrual period; seizures; severe or persistent nausea, stomach pain, or vomiting; symptoms of bleeding (eg, vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; unusual vaginal bleeding; bruises without a reason or that get bigger; any bleeding that is severe or that you cannot stop); symptoms of infection (eg, fever, chills, sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, painful urination, mouth sores, wound that will not heal, anal itching or pain); symptoms of lung problems (eg, shortness of breath or other trouble breathing, cough, fever); unusual tiredness or weakness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Myleran:

Store Myleran at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Myleran out of the reach of children and away from pets.

General information:

  • If you have any questions about Myleran, please talk with your doctor, pharmacist, or other health care provider.
  • Myleran is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Myleran or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Myleran. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Myleran. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Myleran.

Issue Date: June 3, 2015
Database Edition 15.2.1.003
Copyright © 2015 Clinical Drug Information, LLC

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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