Busulfan use while Breastfeeding

Drugs containing Busulfan: Busulfex, Myleran

Busulfan Levels and Effects while Breastfeeding

Summary of Use during Lactation

Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Busulfan in a dosage of 4 mg daily for 5 weeks was taken for myeloid leukemia by one woman while breastfeeding. Weekly monitoring found no adverse effects on her infant's leukocyte count or hemoglobin.[1]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. Bounameaux Y, Durenne JM. [A case of leukemia in a lactating female: effect of treatment with busulfan on the infant]. Ann Soc Belge Med Trop. 1964;44:381-3. PMID: 14259241

Busulfan Identification

Substance Name

Busulfan

CAS Registry Number

55-98-1

Drug Class

Antineoplastic Agents

Administrative Information

LactMed Record Number

37

Last Revision Date

20130907

Disclaimer

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